Effect of biomaterial surfaces and tissue substrates on human smooth muscle cell proliferation under PDGF stimulus

M. Santin, M. Harrison, C. Morris, L. Mikhalovska, S. Fields, D. Teer, S. Mikhalovsky

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The adhesion and proliferation of human smooth muscle cell (SMC) was studied in the absence or presence of a platelet-derived growth factor (PDGF) stimulus on biomaterial surfaces. Cell adhesion was assessed by using fluorescence microscopy after they were stained with 5μg/ml of phalloidin-rhodamin. It was found that there was a lower proliferation rate on diamond-like carbon (DLC) and fibrin at 72 h as compared to other substrates. It was observed that SMC proliferation was stimulated in the extracellular matrix (ECM) of the vessel wall, but inhibited by DLC-based coatings.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - Dec 1 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Santin, M., Harrison, M., Morris, C., Mikhalovska, L., Fields, S., Teer, D., & Mikhalovsky, S. (2004). Effect of biomaterial surfaces and tissue substrates on human smooth muscle cell proliferation under PDGF stimulus. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).