Abstract
Adult male rats were fed a goitrogen, aminotriazole, for 74 days at a dose known to suppress thyroid function completely. At the end of this period, these animals along with matched controls were killed in groups of seven at 3 hourly intervals throughout a 24 hour period, and serum TSH, T3, T4 and albumin assayed. No significant circadian rhythms to T3,T4 or albumin were found in either, but a highly significant rhythm of TSH was demonstrated both in controls and goitrogen treated groups, with a diminished relative amplitude in the latter. The results indicate that a significant diurnal rhythm of serum TSH persists in the rat despite long term blockade of thyroid hormone synthesis and that the existence of this rhythm is therefore independent of the presence of circulating T3 or T4.
| Original language | English |
|---|---|
| Pages (from-to) | 396-401 |
| Number of pages | 6 |
| Journal | Acta Endocrinologica |
| Volume | 98 |
| Issue number | 3 |
| Publication status | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
Cite this
Effect of goitrogen administration on the circadian rhythm of serum thyroid stimulating hormone in the rat. / Stringer, B.; Wynford-Thomas, D.; Jasani, B.; Williams, E. D.
In: Acta Endocrinologica, Vol. 98, No. 3, 1981, p. 396-401.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of goitrogen administration on the circadian rhythm of serum thyroid stimulating hormone in the rat
AU - Stringer, B.
AU - Wynford-Thomas, D.
AU - Jasani, B.
AU - Williams, E. D.
PY - 1981
Y1 - 1981
N2 - Adult male rats were fed a goitrogen, aminotriazole, for 74 days at a dose known to suppress thyroid function completely. At the end of this period, these animals along with matched controls were killed in groups of seven at 3 hourly intervals throughout a 24 hour period, and serum TSH, T3, T4 and albumin assayed. No significant circadian rhythms to T3,T4 or albumin were found in either, but a highly significant rhythm of TSH was demonstrated both in controls and goitrogen treated groups, with a diminished relative amplitude in the latter. The results indicate that a significant diurnal rhythm of serum TSH persists in the rat despite long term blockade of thyroid hormone synthesis and that the existence of this rhythm is therefore independent of the presence of circulating T3 or T4.
AB - Adult male rats were fed a goitrogen, aminotriazole, for 74 days at a dose known to suppress thyroid function completely. At the end of this period, these animals along with matched controls were killed in groups of seven at 3 hourly intervals throughout a 24 hour period, and serum TSH, T3, T4 and albumin assayed. No significant circadian rhythms to T3,T4 or albumin were found in either, but a highly significant rhythm of TSH was demonstrated both in controls and goitrogen treated groups, with a diminished relative amplitude in the latter. The results indicate that a significant diurnal rhythm of serum TSH persists in the rat despite long term blockade of thyroid hormone synthesis and that the existence of this rhythm is therefore independent of the presence of circulating T3 or T4.
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M3 - Article
C2 - 7293669
AN - SCOPUS:0019840746
VL - 98
SP - 396
EP - 401
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 3
ER -