Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cross-sectional study

Gianfranco Sfregola, Pamela Sfregola, Federico Ruta, Federica Zendoli, Alessandra Musicco, Simone Garzon, Stefano Uccella, Andrea Etrusco, Vito Chiantera, Sanja Terzic, Andrea Giannini, Antonio Simone Laganà

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The aim of this study was to evaluate the effect of maternal age and body mass index (BMI) on induction of labor with oral misoprostol for premature rupture of membrane (PROM) at term. We have conducted retrospective cross-sectional study, including only term (37 weeks or more of gestation) PROM in healthy nulliparous women with a negative vaginal-rectal swab for group B streptococcus, a single cephalic fetus with normal birthweight, and uneventful pregnancy that were induced after 24 h from PROM. Ninety-one patients were included. According to the multivariate logistic regression, age and BMI odds ratio (OR) for induction success were 0.795 and 0.857, respectively. The study population was divided into two groups based on age (<35 and ≥35 years) and obesity (BMI <30 and ≥30). Older women reported a higher induction failure rate (p < 0.001); longer time to cervical dilation of 6 cm (p = 0.03) and delivery (p < 0.001). Obese women reported a higher induction failure rate (p = 0.01); number of misoprostol doses (p = 0.03), longer time of induction (p = 0.03) to cervical dilatation of 6 cm (p < 0.001), and delivery (p < 0.001); and higher cesarean section (p = 0.012) and episiotomy rate (p = 0.007). In conclusion, maternal age and BMI are two of the main factors that influence oral misoprostol efficacy and affect the failure of induction rate in term PROM.

Original languageEnglish
Article number20230747
JournalOpen Medicine (Poland)
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 2023
Externally publishedYes

Keywords

  • age
  • body mass index
  • cervical ripening
  • labor induction
  • oral misoprostol
  • premature rupture of membrane

ASJC Scopus subject areas

  • General Medicine

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