Effect of particle shape of active pharmaceutical ingredients prepared by fluidized-bed jet-milling on cohesiveness

Tadashi Fukunaka, Kohta Sawaguchi, Boris Golman, Kunio Shinohara

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Milling is a common procedure to improve bioavailability of many active pharmaceutical ingredients (APIs), which typically have low solubility in water. But such micronization can yield an increase in the cohesiveness of particles. Although particle cohesiveness is desirable for tablet strength in the subsequent formulation process, increased particle cohesiveness can lead to operational difficulties in a milling equipment due to compaction of particles inside. In this article, the impact of milling via a fluidized-bed jet-mill on the cohesive strength and interparticle force was studied using Ethenzamide as a pharmaceutical model compound. As a result, the particle shape was found to affect both the tensile strength of powder bed and the interparticle cohesive force. A powder bed, having relatively high void fraction by direct tensile test, shows a positive correlation between the cohesive force and the particle sphericity, while powders with low void fraction by diametral compression test show a positive correlation between the cohesive force and the angularity of the particle.

Original languageEnglish
Pages (from-to)1004-1012
Number of pages9
JournalJournal of Pharmaceutical Sciences
Volume94
Issue number5
DOIs
Publication statusPublished - May 2005

Keywords

  • Active pharmaceutical ingredients
  • Cohesive force
  • Compression
  • Particle shape
  • Powder technology
  • Tableting
  • Tensile strength

ASJC Scopus subject areas

  • Pharmaceutical Science

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