Vliianie limfotsitozstimuliruiushchego faktora Bordetella pertussis na limfoidnye i krovetvornye kletki mysheǐ.

Translated title of the contribution: Effect of the lymphocytosis-stimulating factor from Bordetella pertussis on murine lymphoid and hemopoietic cells

A. A. Gureeva, A. V. Sanin, V. O. Rybin, N. S. Barteneva, I. A. Lapaeva

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Effect of B. pertussis lymphocytosis-promoting factor (LPF) on the lympho-hematopoietic system of mice was studied. The injection of LPF was shown to sharply enhance endogenous colony formation and to induce a severe depletion of thymus cells, reaching its maximum of day 4. Thymocytes obtained on day 2 or 3 after the injection of LPF produced a suppressive effect on endogenous colony formation. The proliferative activity of hematopoietic stem cells sharply increased under the influence of LPF, though it had no radioprotective action. On the following day after the injection of LPF a steep rise in the number of hematopoietic stem cells was observed in the blood of mice: their content increased 20-fold in comparison with the control level. These data may be important for the evaluation of the side effects of pertussis vaccine on the lympho-hematopoietic system.

Original languageRussian
Pages (from-to)63-66
Number of pages4
JournalZhurnal mikrobiologii, epidemiologii, i immunobiologii
Issue number5
Publication statusPublished - May 1986
Externally publishedYes

Fingerprint

Lymphocytosis
Bordetella pertussis
Pertussis Toxin
Lymphocytes
Hematopoietic System
Hematopoietic Stem Cells
Injections
Pertussis Vaccine
Thymocytes
Thymus Gland

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vliianie limfotsitozstimuliruiushchego faktora Bordetella pertussis na limfoidnye i krovetvornye kletki mysheǐ. / Gureeva, A. A.; Sanin, A. V.; Rybin, V. O.; Barteneva, N. S.; Lapaeva, I. A.

In: Zhurnal mikrobiologii, epidemiologii, i immunobiologii, No. 5, 05.1986, p. 63-66.

Research output: Contribution to journalArticle

@article{7120e519edb5487f90c6395df848fa2f,
title = "Vliianie limfotsitozstimuliruiushchego faktora Bordetella pertussis na limfoidnye i krovetvornye kletki mysheǐ.",
abstract = "Effect of B. pertussis lymphocytosis-promoting factor (LPF) on the lympho-hematopoietic system of mice was studied. The injection of LPF was shown to sharply enhance endogenous colony formation and to induce a severe depletion of thymus cells, reaching its maximum of day 4. Thymocytes obtained on day 2 or 3 after the injection of LPF produced a suppressive effect on endogenous colony formation. The proliferative activity of hematopoietic stem cells sharply increased under the influence of LPF, though it had no radioprotective action. On the following day after the injection of LPF a steep rise in the number of hematopoietic stem cells was observed in the blood of mice: their content increased 20-fold in comparison with the control level. These data may be important for the evaluation of the side effects of pertussis vaccine on the lympho-hematopoietic system.",
author = "Gureeva, {A. A.} and Sanin, {A. V.} and Rybin, {V. O.} and Barteneva, {N. S.} and Lapaeva, {I. A.}",
year = "1986",
month = "5",
language = "Russian",
pages = "63--66",
journal = "Zhurnal Mikrobiologii Epidemiologii i Immunobiologii",
issn = "0372-9311",
publisher = "Izdatel'stvo S-Info",
number = "5",

}

TY - JOUR

T1 - Vliianie limfotsitozstimuliruiushchego faktora Bordetella pertussis na limfoidnye i krovetvornye kletki mysheǐ.

AU - Gureeva, A. A.

AU - Sanin, A. V.

AU - Rybin, V. O.

AU - Barteneva, N. S.

AU - Lapaeva, I. A.

PY - 1986/5

Y1 - 1986/5

N2 - Effect of B. pertussis lymphocytosis-promoting factor (LPF) on the lympho-hematopoietic system of mice was studied. The injection of LPF was shown to sharply enhance endogenous colony formation and to induce a severe depletion of thymus cells, reaching its maximum of day 4. Thymocytes obtained on day 2 or 3 after the injection of LPF produced a suppressive effect on endogenous colony formation. The proliferative activity of hematopoietic stem cells sharply increased under the influence of LPF, though it had no radioprotective action. On the following day after the injection of LPF a steep rise in the number of hematopoietic stem cells was observed in the blood of mice: their content increased 20-fold in comparison with the control level. These data may be important for the evaluation of the side effects of pertussis vaccine on the lympho-hematopoietic system.

AB - Effect of B. pertussis lymphocytosis-promoting factor (LPF) on the lympho-hematopoietic system of mice was studied. The injection of LPF was shown to sharply enhance endogenous colony formation and to induce a severe depletion of thymus cells, reaching its maximum of day 4. Thymocytes obtained on day 2 or 3 after the injection of LPF produced a suppressive effect on endogenous colony formation. The proliferative activity of hematopoietic stem cells sharply increased under the influence of LPF, though it had no radioprotective action. On the following day after the injection of LPF a steep rise in the number of hematopoietic stem cells was observed in the blood of mice: their content increased 20-fold in comparison with the control level. These data may be important for the evaluation of the side effects of pertussis vaccine on the lympho-hematopoietic system.

UR - http://www.scopus.com/inward/record.url?scp=0022708857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022708857&partnerID=8YFLogxK

M3 - Article

SP - 63

EP - 66

JO - Zhurnal Mikrobiologii Epidemiologii i Immunobiologii

JF - Zhurnal Mikrobiologii Epidemiologii i Immunobiologii

SN - 0372-9311

IS - 5

ER -