Effect of transmembrane pressure on rejection of viruses by ultrafiltration membranes

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65 Citations (Scopus)


Although partial penetration of ultrafiltration membranes by viruses and bacteria is well documented, there is no satisfactory explanation for the phenomenon. The current study seeks a possible explanation by studying the retention of viruses at different transmembrane pressures (TMPs). In contrast to previous predictions, higher TMPs lead to reduced virus retention levels. Based on indirect evidences it is proposed that the penetration occurs because of the formation during operation, rather than the initial presence, of abnormally large pores. It is therefore suggested that since pore enlargement is induced by high TMPs, high virus retention levels can be obtained only at low TMP values.

Original languageEnglish
Pages (from-to)619-628
Number of pages10
JournalSeparation and Purification Technology
Issue number3
Publication statusPublished - Sept 22 2008


  • E. coli
  • MS2
  • PES membrane
  • T4
  • phi X174

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation


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