Efficacy of therapy of different variants of anaplastic large T-cell lymphomas

Yu E. Vinogradova, I. N. Lutsenko, I. B. Kaplanskaya, I. A. Vorobyev, R. S. Samoilova, L. A. Gorgidze, N. A. Ryzhkova, T. T. Valiev, E. A. Gilyazitdinova, U. L. Dzhulakyan, E. K. Egorova, E. E. Zvonkov, B. B. Krasilnikova, A. U. Magomedova, O. V. Margolin, D. S. Maryin, A. M. Kremenetskaya, S. K. Kravchenko, A. I. Vorobyev

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Aim. To compare efficacy of NHL-BFM-90 and CHOP-like courses in the treatment of anaplastic large cell lymphoma (ALCL). Material and methods. Twenty-two patients with ALCL participated in the study. The diagnosis was made basing on the findings of clinical, device, morphological, immunohistochemical and molecular-genetic examinations with application of a panel of monoclonal antibodies to CD30, ALK, CD3, CD4, CD8, CD7, CD34, CD15, CD68, CD20, CD45RO, CD45RA, Ki-67. 14 cases of 22 were negative by kinase of anaplastic lymphocytes (ALK-) and 8 were ppositive (ALK+). Mean age of ALK-ALCL patients was 39.6 ± 4.1 years, of ALK+ALCL patients - 23.4 ± 2.6years. 14 patients were treated by the protocol NHL-BFM-90, 8 were initially treated with other schemes (CHOP, MACOP-B, BEACOPP and others). All 14 patients treated according to NHL-BFM-90 had ALCL stages III-IV with B-symptoms. 12 patients who completed treatment by the above protocol achieved complete remission after the forth course, 2 patients failed the treatment. Of 8 ALCL patients treated initially according to other schemes, a complete remission was achieved in 4 patients (2 had stage II). One of 4 patients with remission had recurrence. Four patients who had failed to achieve complete remission died of the disease progression. Conclusion. ALCL occurs more frequently in young and middle-aged patients. The disease has an aggressive course with rapid generalization. For such processes it is more preferable to use a modified protocol NHL-BFM-90.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalTerapevticheskii Arkhiv
Volume80
Issue number7
Publication statusPublished - Sep 11 2008

Keywords

  • Anaplastic large cell lymphoma
  • NHL-BFM-90
  • Therapy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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