Abstract
Elemental metabolomics is quantification and characterization of total concentration of chemical elements in biological samples and monitoring of their changes. Recent advances in inductively coupled plasma mass spectrometry have enabled simultaneous measurement of concentrations of > 70 elements in biological samples. In living organisms, elements interact and compete with each other for absorption and molecular interactions. They also interact with proteins and nucleotide sequences. These interactions modulate enzymatic activities and are critical for many molecular and cellular functions. Testing for concentration of > 40 elements in blood, other bodily fluids and tissues is now in routine use in advanced medical laboratories. In this article, we define the basic concepts of elemental metabolomics, summarize standards and workflows, and propose minimuminformation for reporting the results of an elemental metabolomics experiment. Major statistical and informatics tools for elemental metabolomics are reviewed, and examples of applications are discussed. Elemental metabolomics is emerging as an important new technology with applications in medical diagnostics, nutrition, agriculture, food science, environmental science and multiplicity of other areas.
| Original language | English |
|---|---|
| Pages (from-to) | 524-536 |
| Number of pages | 13 |
| Journal | Briefings in Bioinformatics |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1 2018 |
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Keywords
- Biomonitoring
- Chemometrics
- Clinical laboratory testing
- Ionomics
- Metallomics
- Mineralomics
ASJC Scopus subject areas
- Information Systems
- Molecular Biology
Cite this
Elemental metabolomics. / Zhang, Ping; Georgiou, Constantinos A.; Brusic, Vladimir.
In: Briefings in Bioinformatics, Vol. 19, No. 3, 01.05.2018, p. 524-536.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elemental metabolomics
AU - Zhang, Ping
AU - Georgiou, Constantinos A.
AU - Brusic, Vladimir
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Elemental metabolomics is quantification and characterization of total concentration of chemical elements in biological samples and monitoring of their changes. Recent advances in inductively coupled plasma mass spectrometry have enabled simultaneous measurement of concentrations of > 70 elements in biological samples. In living organisms, elements interact and compete with each other for absorption and molecular interactions. They also interact with proteins and nucleotide sequences. These interactions modulate enzymatic activities and are critical for many molecular and cellular functions. Testing for concentration of > 40 elements in blood, other bodily fluids and tissues is now in routine use in advanced medical laboratories. In this article, we define the basic concepts of elemental metabolomics, summarize standards and workflows, and propose minimuminformation for reporting the results of an elemental metabolomics experiment. Major statistical and informatics tools for elemental metabolomics are reviewed, and examples of applications are discussed. Elemental metabolomics is emerging as an important new technology with applications in medical diagnostics, nutrition, agriculture, food science, environmental science and multiplicity of other areas.
AB - Elemental metabolomics is quantification and characterization of total concentration of chemical elements in biological samples and monitoring of their changes. Recent advances in inductively coupled plasma mass spectrometry have enabled simultaneous measurement of concentrations of > 70 elements in biological samples. In living organisms, elements interact and compete with each other for absorption and molecular interactions. They also interact with proteins and nucleotide sequences. These interactions modulate enzymatic activities and are critical for many molecular and cellular functions. Testing for concentration of > 40 elements in blood, other bodily fluids and tissues is now in routine use in advanced medical laboratories. In this article, we define the basic concepts of elemental metabolomics, summarize standards and workflows, and propose minimuminformation for reporting the results of an elemental metabolomics experiment. Major statistical and informatics tools for elemental metabolomics are reviewed, and examples of applications are discussed. Elemental metabolomics is emerging as an important new technology with applications in medical diagnostics, nutrition, agriculture, food science, environmental science and multiplicity of other areas.
KW - Biomonitoring
KW - Chemometrics
KW - Clinical laboratory testing
KW - Ionomics
KW - Metallomics
KW - Mineralomics
UR - http://www.scopus.com/inward/record.url?scp=85033200749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033200749&partnerID=8YFLogxK
U2 - 10.1093/bib/bbw131
DO - 10.1093/bib/bbw131
M3 - Article
C2 - 28077402
AN - SCOPUS:85033200749
VL - 19
SP - 524
EP - 536
JO - Briefings in Bioinformatics
JF - Briefings in Bioinformatics
SN - 1467-5463
IS - 3
ER -