Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in Chronic Kidney Disease

Yeldar Baiken; Zhannur Markhametova; Assem Ashimova; Ainur Zhulamanova; Assem Nogaibayeva; Larissa Kozina; Bakhyt Matkarimov; Bauyrzhan Aituov; Abduzhappar Gaipov; Askhat Myngbay

doi:10.3390/medicina59040651

Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in Chronic Kidney Disease

Yeldar Baiken
, Zhannur Markhametova
, Assem Ashimova
, Ainur Zhulamanova
, Assem Nogaibayeva
, Larissa Kozina
, Bakhyt Matkarimov
, Bauyrzhan Aituov
, Abduzhappar Gaipov
, Askhat Myngbay

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: Chronic kidney disease (CKD) has various etiologies, making it impossible to fully understand its complex pathophysiology. Elevated levels of plasma creatinine, proteinuria, and albuminuria and declined eGFR are traits observed in CKD patients. The current study attempts to highlight the collagen triple helix repeat containing 1 (CTHRC1) protein as a putative blood biomarker for CKD in addition to existing recognized indicators of CKD progression. Methods: A total of 26 CKD patients and 18 healthy controls were enrolled in this study. Clinical characteristics and complete blood and biochemical analyses were collected, and human ELISA kits were used to detect possible CKD biomarkers. Results: The study’s findings showed that CTHRC1 correlates with key clinical markers of kidney function such as 24 h urine total protein, creatinine, urea, and uric acid. In addition, CTHRC1 demonstrated a strong significant difference (p ≤ 0.0001) between the CKD and control group. Conclusions: Our research demonstrates that the plasma level of CTHRC1 can distinguish between those with CKD and healthy patients. Plasma CTHRC1 levels may aid in the diagnosis of CKD given the current state of knowledge, and these results call for further investigation in a wider, more diverse patient group.

Original language	English
Article number	651
Pages (from-to)	651
Number of pages	1
Journal	Medicina
Volume	59
Issue number	4
DOIs	https://doi.org/10.3390/medicina59040651
Publication status	Published - Apr 2023

Funding

The study was funded by the Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan grant AP09260233 for Y.B. and B.M., Nazarbayev University Collaborative Research Program (CRP) for 2020–2022 (Funder Project Reference: 091019CRP2105) to A.G. and CRP 091019CRP2111 to B.M. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. All authors had full access to all the data in the study, and the lead authors (Y.B., A.M., A.G.) had final responsibility for the decision to submit manuscript for publication.

Funders	Funder number
Ministry of Education and Science of the Republic of Kazakhstan	AP09260233
Nazarbayev University	091019CRP2105, CRP 091019CRP2111

Keywords

CKD
CTHRC1
chronic kidney disease
glomerulonephritis
kidney disease

ASJC Scopus subject areas

General Medicine

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10.3390/medicina59040651

https://doi.org/10.3390%2Fmedicina59040651

Cite this

Baiken, Y., Markhametova, Z., Ashimova, A., Zhulamanova, A., Nogaibayeva, A., Kozina, L., Matkarimov, B., Aituov, B., Gaipov, A., & Myngbay, A. (2023). Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in Chronic Kidney Disease. Medicina, 59(4), 651. Article 651. https://doi.org/10.3390/medicina59040651

Baiken, Y, Markhametova, Z, Ashimova, A, Zhulamanova, A, Nogaibayeva, A, Kozina, L, Matkarimov, B, Aituov, B, Gaipov, A & Myngbay, A 2023, 'Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in Chronic Kidney Disease', Medicina, vol. 59, no. 4, 651, pp. 651. https://doi.org/10.3390/medicina59040651

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abstract = "Background: Chronic kidney disease (CKD) has various etiologies, making it impossible to fully understand its complex pathophysiology. Elevated levels of plasma creatinine, proteinuria, and albuminuria and declined eGFR are traits observed in CKD patients. The current study attempts to highlight the collagen triple helix repeat containing 1 (CTHRC1) protein as a putative blood biomarker for CKD in addition to existing recognized indicators of CKD progression. Methods: A total of 26 CKD patients and 18 healthy controls were enrolled in this study. Clinical characteristics and complete blood and biochemical analyses were collected, and human ELISA kits were used to detect possible CKD biomarkers. Results: The study{\textquoteright}s findings showed that CTHRC1 correlates with key clinical markers of kidney function such as 24 h urine total protein, creatinine, urea, and uric acid. In addition, CTHRC1 demonstrated a strong significant difference (p ≤ 0.0001) between the CKD and control group. Conclusions: Our research demonstrates that the plasma level of CTHRC1 can distinguish between those with CKD and healthy patients. Plasma CTHRC1 levels may aid in the diagnosis of CKD given the current state of knowledge, and these results call for further investigation in a wider, more diverse patient group.",

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AU - Ashimova, Assem

AU - Zhulamanova, Ainur

AU - Nogaibayeva, Assem

AU - Kozina, Larissa

AU - Matkarimov, Bakhyt

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AU - Myngbay, Askhat

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AB - Background: Chronic kidney disease (CKD) has various etiologies, making it impossible to fully understand its complex pathophysiology. Elevated levels of plasma creatinine, proteinuria, and albuminuria and declined eGFR are traits observed in CKD patients. The current study attempts to highlight the collagen triple helix repeat containing 1 (CTHRC1) protein as a putative blood biomarker for CKD in addition to existing recognized indicators of CKD progression. Methods: A total of 26 CKD patients and 18 healthy controls were enrolled in this study. Clinical characteristics and complete blood and biochemical analyses were collected, and human ELISA kits were used to detect possible CKD biomarkers. Results: The study’s findings showed that CTHRC1 correlates with key clinical markers of kidney function such as 24 h urine total protein, creatinine, urea, and uric acid. In addition, CTHRC1 demonstrated a strong significant difference (p ≤ 0.0001) between the CKD and control group. Conclusions: Our research demonstrates that the plasma level of CTHRC1 can distinguish between those with CKD and healthy patients. Plasma CTHRC1 levels may aid in the diagnosis of CKD given the current state of knowledge, and these results call for further investigation in a wider, more diverse patient group.

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Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in Chronic Kidney Disease

Abstract

Funding

Keywords

ASJC Scopus subject areas

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