Elevated serum CA 19-9 levels in hepatobiliary cystadenoma with mesenchymal stroma

Two case reports with immunohistochemical confirmation

J. A. Thomas, M. W. Scriven, M. C A Puntis, B. Jasani, G. T. Williams

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Hepatobiliary cystadenomas with mesenchymal stroma (CMS) are rare tumors. Two cases are reported that illustrate many features of CMS, including polypoid involvement of the common hepatic duct in one case. Both tumors were associated with elevated serum levels of the tumor-associated antigen CA 19-9 but normal levels of carcinoembryonic antigen and alpha-fetoprotein. Immunohistochemical analysis confirmed the presence of CA 19-9 in the epithelial component of the tumor. The implications of these findings are discussed, both in relation to the histogenesis of CMS and its preoperative diagnosis. A minimally elevated level of CA 19-9 was found in only one of five patients with hydatid disease of the liver, an important differential diagnosis in clinical management.

Original languageEnglish
Pages (from-to)1841-1846
Number of pages6
JournalCancer
Volume70
Issue number7
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Cystadenoma
Serum
Common Hepatic Duct
Neoplasms
Carcinoembryonic Antigen
alpha-Fetoproteins
Neoplasm Antigens
Liver Diseases
Differential Diagnosis

Keywords

  • CA 19-9
  • cystadenoma
  • immunohistochemistry
  • liver neoplasms
  • tumor markers

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Thomas, J. A., Scriven, M. W., Puntis, M. C. A., Jasani, B., & Williams, G. T. (1992). Elevated serum CA 19-9 levels in hepatobiliary cystadenoma with mesenchymal stroma: Two case reports with immunohistochemical confirmation. Cancer, 70(7), 1841-1846.

Elevated serum CA 19-9 levels in hepatobiliary cystadenoma with mesenchymal stroma : Two case reports with immunohistochemical confirmation. / Thomas, J. A.; Scriven, M. W.; Puntis, M. C A; Jasani, B.; Williams, G. T.

In: Cancer, Vol. 70, No. 7, 1992, p. 1841-1846.

Research output: Contribution to journalArticle

Thomas, JA, Scriven, MW, Puntis, MCA, Jasani, B & Williams, GT 1992, 'Elevated serum CA 19-9 levels in hepatobiliary cystadenoma with mesenchymal stroma: Two case reports with immunohistochemical confirmation', Cancer, vol. 70, no. 7, pp. 1841-1846.
Thomas, J. A. ; Scriven, M. W. ; Puntis, M. C A ; Jasani, B. ; Williams, G. T. / Elevated serum CA 19-9 levels in hepatobiliary cystadenoma with mesenchymal stroma : Two case reports with immunohistochemical confirmation. In: Cancer. 1992 ; Vol. 70, No. 7. pp. 1841-1846.
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