Emergence of HIV-1 Unique DG Recombinant Form in Pakistan

Uroosa Tariq, Faisal Mahmood, Sadaf Naeem, Syed Ali, Syed Hani Abidi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

After the first case of HIV infection in 1987, the number of cases has continuously increased in Pakistan, turning from isolated incidents to outbreaks to the concentrated epidemic. The HIV epidemic in Pakistan is mainly driven by subtype A; however, the overlapping transmission chains facilitate recombination between subtypes and existing circulating recombinants forms (CRFs), leading to the emergence of unique recombinant forms (URFs). In this study, we report the first case of a URF (URF-DG) in a Pakistani HIV-infected patient. Phylogenetic and drug resistance analysis of the patient-derived sequence indicated that Pakistani URF-DG sequence was closely related to the URF-DG sequence reported from the United Kingdom, but had more drug resistance mutations than the U.K. sequence.

Original languageEnglish
Pages (from-to)248-250
Number of pages3
JournalAIDS Research and Human Retroviruses
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 2020

Keywords

  • Antiretroviral therapies
  • Epidemiology
  • HIV evolution
  • Phylogenetics

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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