Emergence of HIV-1 Unique DG Recombinant Form in Pakistan

Uroosa Tariq; Faisal Mahmood; Sadaf Naeem; Syed Ali; Syed Hani Abidi

doi:10.1089/aid.2019.0183

Emergence of HIV-1 Unique DG Recombinant Form in Pakistan

Uroosa Tariq, Faisal Mahmood, Sadaf Naeem, Syed Ali, Syed Hani Abidi

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

After the first case of HIV infection in 1987, the number of cases has continuously increased in Pakistan, turning from isolated incidents to outbreaks to the concentrated epidemic. The HIV epidemic in Pakistan is mainly driven by subtype A; however, the overlapping transmission chains facilitate recombination between subtypes and existing circulating recombinants forms (CRFs), leading to the emergence of unique recombinant forms (URFs). In this study, we report the first case of a URF (URF-DG) in a Pakistani HIV-infected patient. Phylogenetic and drug resistance analysis of the patient-derived sequence indicated that Pakistani URF-DG sequence was closely related to the URF-DG sequence reported from the United Kingdom, but had more drug resistance mutations than the U.K. sequence.

Original language	English
Pages (from-to)	248-250
Number of pages	3
Journal	AIDS Research and Human Retroviruses
Volume	36
Issue number	3
DOIs	https://doi.org/10.1089/aid.2019.0183
Publication status	Published - Mar 2020

Keywords

Antiretroviral therapies
Epidemiology
HIV evolution
Phylogenetics

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

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title = "Emergence of HIV-1 Unique DG Recombinant Form in Pakistan",

abstract = "After the first case of HIV infection in 1987, the number of cases has continuously increased in Pakistan, turning from isolated incidents to outbreaks to the concentrated epidemic. The HIV epidemic in Pakistan is mainly driven by subtype A; however, the overlapping transmission chains facilitate recombination between subtypes and existing circulating recombinants forms (CRFs), leading to the emergence of unique recombinant forms (URFs). In this study, we report the first case of a URF (URF-DG) in a Pakistani HIV-infected patient. Phylogenetic and drug resistance analysis of the patient-derived sequence indicated that Pakistani URF-DG sequence was closely related to the URF-DG sequence reported from the United Kingdom, but had more drug resistance mutations than the U.K. sequence.",

keywords = "Antiretroviral therapies, Epidemiology, HIV evolution, Phylogenetics",

author = "Uroosa Tariq and Faisal Mahmood and Sadaf Naeem and Syed Ali and Abidi, {Syed Hani}",

note = "Funding Information: This research was funded by Aga Khan University Seed Money grant no. PF84/0716, Higher Education Commission grant no. 5217/Sindh/NRPU/R&D/HEC/2016 and Pakistan Science Foundation grant no. PSF/Res/S-AKU/Med (488). Publisher Copyright: {\textcopyright} Copyright 2020, Mary Ann Liebert, Inc.",

year = "2020",

month = mar,

doi = "10.1089/aid.2019.0183",

language = "English",

volume = "36",

pages = "248--250",

journal = "AIDS Research and Human Retroviruses",

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AU - Tariq, Uroosa

AU - Mahmood, Faisal

AU - Naeem, Sadaf

AU - Ali, Syed

AU - Abidi, Syed Hani

N1 - Funding Information: This research was funded by Aga Khan University Seed Money grant no. PF84/0716, Higher Education Commission grant no. 5217/Sindh/NRPU/R&D/HEC/2016 and Pakistan Science Foundation grant no. PSF/Res/S-AKU/Med (488). Publisher Copyright: © Copyright 2020, Mary Ann Liebert, Inc.

PY - 2020/3

Y1 - 2020/3

N2 - After the first case of HIV infection in 1987, the number of cases has continuously increased in Pakistan, turning from isolated incidents to outbreaks to the concentrated epidemic. The HIV epidemic in Pakistan is mainly driven by subtype A; however, the overlapping transmission chains facilitate recombination between subtypes and existing circulating recombinants forms (CRFs), leading to the emergence of unique recombinant forms (URFs). In this study, we report the first case of a URF (URF-DG) in a Pakistani HIV-infected patient. Phylogenetic and drug resistance analysis of the patient-derived sequence indicated that Pakistani URF-DG sequence was closely related to the URF-DG sequence reported from the United Kingdom, but had more drug resistance mutations than the U.K. sequence.

AB - After the first case of HIV infection in 1987, the number of cases has continuously increased in Pakistan, turning from isolated incidents to outbreaks to the concentrated epidemic. The HIV epidemic in Pakistan is mainly driven by subtype A; however, the overlapping transmission chains facilitate recombination between subtypes and existing circulating recombinants forms (CRFs), leading to the emergence of unique recombinant forms (URFs). In this study, we report the first case of a URF (URF-DG) in a Pakistani HIV-infected patient. Phylogenetic and drug resistance analysis of the patient-derived sequence indicated that Pakistani URF-DG sequence was closely related to the URF-DG sequence reported from the United Kingdom, but had more drug resistance mutations than the U.K. sequence.

KW - Antiretroviral therapies

KW - Epidemiology

KW - HIV evolution

KW - Phylogenetics

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Emergence of HIV-1 Unique DG Recombinant Form in Pakistan

Abstract

Keywords

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