Abstract
Monodisperse poly(dl-lactic acid) (PLA) particles of diameters between 11 and 121 μm were fabricated in flow focusing glass microcapillary devices by evaporation of dichloromethane (DCM) from emulsion droplets at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing 0.1-2 mM Nile Red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the diameter of the emulsion droplet template, indicating very low particle porosity. Monodisperse droplets have only been produced under dripping regime using a wide range of dispersed phase flow rates (0.002-7.2 cm3·h-1), continuous phase flow rates (0.3-30 cm3·h-1), and orifice diameters (50-237 μm). In the dripping regime, the ratio of droplet diameter to orifice diameter was inversely proportional to the 0.39 power of the ratio of the continuous phase flow rate to dispersed phase flow rate. Highly uniform droplets with a coefficient of variation (CV) below 2% and a ratio of the droplet diameter to orifice diameter of 0.5-1 were obtained at flow rate ratios of 4-25. Under jetting regime, polydisperse droplets (CV > 6%) were formed by detachment from relatively long jets (between 4 and 10 times longer than droplet diameter) and a ratio of the droplet size to orifice size of 2-5.
| Original language | English |
|---|---|
| Pages (from-to) | 12948-12954 |
| Number of pages | 7 |
| Journal | Langmuir |
| Volume | 28 |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - Sep 11 2012 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Electrochemistry
- Condensed Matter Physics
- Surfaces and Interfaces
- Materials Science(all)
- Spectroscopy
Cite this
Emulsion templating of poly(lactic acid) particles : Droplet formation behavior. / Vladisavljević, Goran T.; Duncanson, Wynter J.; Shum, Ho Cheung; Weitz, David A.
In: Langmuir, Vol. 28, No. 36, 11.09.2012, p. 12948-12954.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emulsion templating of poly(lactic acid) particles
T2 - Droplet formation behavior
AU - Vladisavljević, Goran T.
AU - Duncanson, Wynter J.
AU - Shum, Ho Cheung
AU - Weitz, David A.
PY - 2012/9/11
Y1 - 2012/9/11
N2 - Monodisperse poly(dl-lactic acid) (PLA) particles of diameters between 11 and 121 μm were fabricated in flow focusing glass microcapillary devices by evaporation of dichloromethane (DCM) from emulsion droplets at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing 0.1-2 mM Nile Red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the diameter of the emulsion droplet template, indicating very low particle porosity. Monodisperse droplets have only been produced under dripping regime using a wide range of dispersed phase flow rates (0.002-7.2 cm3·h-1), continuous phase flow rates (0.3-30 cm3·h-1), and orifice diameters (50-237 μm). In the dripping regime, the ratio of droplet diameter to orifice diameter was inversely proportional to the 0.39 power of the ratio of the continuous phase flow rate to dispersed phase flow rate. Highly uniform droplets with a coefficient of variation (CV) below 2% and a ratio of the droplet diameter to orifice diameter of 0.5-1 were obtained at flow rate ratios of 4-25. Under jetting regime, polydisperse droplets (CV > 6%) were formed by detachment from relatively long jets (between 4 and 10 times longer than droplet diameter) and a ratio of the droplet size to orifice size of 2-5.
AB - Monodisperse poly(dl-lactic acid) (PLA) particles of diameters between 11 and 121 μm were fabricated in flow focusing glass microcapillary devices by evaporation of dichloromethane (DCM) from emulsion droplets at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing 0.1-2 mM Nile Red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the diameter of the emulsion droplet template, indicating very low particle porosity. Monodisperse droplets have only been produced under dripping regime using a wide range of dispersed phase flow rates (0.002-7.2 cm3·h-1), continuous phase flow rates (0.3-30 cm3·h-1), and orifice diameters (50-237 μm). In the dripping regime, the ratio of droplet diameter to orifice diameter was inversely proportional to the 0.39 power of the ratio of the continuous phase flow rate to dispersed phase flow rate. Highly uniform droplets with a coefficient of variation (CV) below 2% and a ratio of the droplet diameter to orifice diameter of 0.5-1 were obtained at flow rate ratios of 4-25. Under jetting regime, polydisperse droplets (CV > 6%) were formed by detachment from relatively long jets (between 4 and 10 times longer than droplet diameter) and a ratio of the droplet size to orifice size of 2-5.
UR - http://www.scopus.com/inward/record.url?scp=84866108686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866108686&partnerID=8YFLogxK
U2 - 10.1021/la302092f
DO - 10.1021/la302092f
M3 - Article
C2 - 22860633
AN - SCOPUS:84866108686
VL - 28
SP - 12948
EP - 12954
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 36
ER -