Emulsion templating of poly(lactic acid) particles: Droplet formation behavior

Goran T. Vladisavljević, Wynter J. Duncanson, Ho Cheung Shum, David A. Weitz

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Monodisperse poly(dl-lactic acid) (PLA) particles of diameters between 11 and 121 μm were fabricated in flow focusing glass microcapillary devices by evaporation of dichloromethane (DCM) from emulsion droplets at room temperature. The dispersed phase was 5% (w/w) PLA in DCM containing 0.1-2 mM Nile Red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in reverse osmosis water. Particle diameter was 2.7 times smaller than the diameter of the emulsion droplet template, indicating very low particle porosity. Monodisperse droplets have only been produced under dripping regime using a wide range of dispersed phase flow rates (0.002-7.2 cm3·h-1), continuous phase flow rates (0.3-30 cm3·h-1), and orifice diameters (50-237 μm). In the dripping regime, the ratio of droplet diameter to orifice diameter was inversely proportional to the 0.39 power of the ratio of the continuous phase flow rate to dispersed phase flow rate. Highly uniform droplets with a coefficient of variation (CV) below 2% and a ratio of the droplet diameter to orifice diameter of 0.5-1 were obtained at flow rate ratios of 4-25. Under jetting regime, polydisperse droplets (CV > 6%) were formed by detachment from relatively long jets (between 4 and 10 times longer than droplet diameter) and a ratio of the droplet size to orifice size of 2-5.

Original languageEnglish
Pages (from-to)12948-12954
Number of pages7
JournalLangmuir
Volume28
Issue number36
DOIs
Publication statusPublished - Sep 11 2012
Externally publishedYes

Fingerprint

lactic acid
Lactic acid
Emulsions
emulsions
orifices
Orifices
flow velocity
Flow rate
Methylene Chloride
Dichloromethane
reverse osmosis
poly(lactic acid)
Reverse osmosis
coefficients
detachment
Lactic Acid
Evaporation
alcohols
Alcohols
templates

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Vladisavljević, G. T., Duncanson, W. J., Shum, H. C., & Weitz, D. A. (2012). Emulsion templating of poly(lactic acid) particles: Droplet formation behavior. Langmuir, 28(36), 12948-12954. https://doi.org/10.1021/la302092f

Emulsion templating of poly(lactic acid) particles : Droplet formation behavior. / Vladisavljević, Goran T.; Duncanson, Wynter J.; Shum, Ho Cheung; Weitz, David A.

In: Langmuir, Vol. 28, No. 36, 11.09.2012, p. 12948-12954.

Research output: Contribution to journalArticle

Vladisavljević, GT, Duncanson, WJ, Shum, HC & Weitz, DA 2012, 'Emulsion templating of poly(lactic acid) particles: Droplet formation behavior', Langmuir, vol. 28, no. 36, pp. 12948-12954. https://doi.org/10.1021/la302092f
Vladisavljević GT, Duncanson WJ, Shum HC, Weitz DA. Emulsion templating of poly(lactic acid) particles: Droplet formation behavior. Langmuir. 2012 Sep 11;28(36):12948-12954. https://doi.org/10.1021/la302092f
Vladisavljević, Goran T. ; Duncanson, Wynter J. ; Shum, Ho Cheung ; Weitz, David A. / Emulsion templating of poly(lactic acid) particles : Droplet formation behavior. In: Langmuir. 2012 ; Vol. 28, No. 36. pp. 12948-12954.
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