Enantioselective synthesis of imperanene via enzymatic asymmetrization of an intermediary 1,3-diol

Jason A. Carr, Kirpal S. Bisht

Research output: Contribution to journalArticle

15 Citations (Scopus)


(Chemical Equation Presented) Using a chemoenzymatic synthetic strategy, (S)-imperanene and its (R)-enantiomer has been synthesized from vanillin in nine steps. The key step in the synthesis involves the use of Pseudomonas cepacia lipase (PS-30) to induce asymmetrization of the intermediary prochiral 1,3-diol in >97% ee.

Original languageEnglish
Pages (from-to)3297-3300
Number of pages4
JournalOrganic Letters
Issue number19
Publication statusPublished - Sep 16 2004


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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