Abstract
Background Endometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). Methods Twenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. Results Of the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03-1.36], P =.01). Conclusions The findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.
| Original language | English |
|---|---|
| Pages (from-to) | 653-658 |
| Number of pages | 6 |
| Journal | Surgery for Obesity and Related Diseases |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 1 2015 |
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Keywords
- Bariatric surgery
- Endometrial cancer
- Endometrial hyperplasia
- Endometrial polyps
- Obesity
- Pipelle sampling
ASJC Scopus subject areas
- Surgery
Cite this
Endometrial histology in severely obese bariatric surgery candidates : An exploratory analysis. / Kaiyrlykyzy, Aiym; Freese, Kyle E.; Elishaev, Esther; Bovbjerg, Dana H.; Ramanathan, Ramesh; Hamad, Giselle G.; McCloskey, Carol; Althouse, Andrew D.; Huang, Marilyn; Edwards, Robert P.; Linkov, Faina.
In: Surgery for Obesity and Related Diseases, Vol. 11, No. 3, 01.05.2015, p. 653-658.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endometrial histology in severely obese bariatric surgery candidates
T2 - An exploratory analysis
AU - Kaiyrlykyzy, Aiym
AU - Freese, Kyle E.
AU - Elishaev, Esther
AU - Bovbjerg, Dana H.
AU - Ramanathan, Ramesh
AU - Hamad, Giselle G.
AU - McCloskey, Carol
AU - Althouse, Andrew D.
AU - Huang, Marilyn
AU - Edwards, Robert P.
AU - Linkov, Faina
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Background Endometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). Methods Twenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. Results Of the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03-1.36], P =.01). Conclusions The findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.
AB - Background Endometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). Methods Twenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. Results Of the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03-1.36], P =.01). Conclusions The findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.
KW - Bariatric surgery
KW - Endometrial cancer
KW - Endometrial hyperplasia
KW - Endometrial polyps
KW - Obesity
KW - Pipelle sampling
UR - http://www.scopus.com/inward/record.url?scp=84931571656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931571656&partnerID=8YFLogxK
U2 - 10.1016/j.soard.2014.12.010
DO - 10.1016/j.soard.2014.12.010
M3 - Article
VL - 11
SP - 653
EP - 658
JO - Surgery for Obesity and Related Diseases
JF - Surgery for Obesity and Related Diseases
SN - 1550-7289
IS - 3
ER -