Abstract
Background: Preoperative differentiation of ovarian malignant tumors still remains a challenge. Diffusion-weighted imaging (DWI) provides information about cellularity of the lesion and might facilitate discrimination between different malignant ovarian lesions. Purpose: To evaluate magnetic resonance imaging (MRI) findings of endometrioid adenocarcinoma of the ovary and to determine the value of DWI in the differential diagnosis of malignant and benign adnexal tumors. Material and Methods: The following MRI findings were reviewed in 162 patients (21 endometrioid adenocarcinoma, 103 other malignant tumors, 38 benign tumors): lesion size, morphological appearance, T2-weighted (T2W) signal intensity, T1-weighted (T1W) signal intensity, contrast-enhancement pattern, DWI signals with apparent diffusion coefficient (ADC) calculated for b800 s/mm2 in solid tumor components. Results: The most common morphological appearance was predominantly cystic lesion, found in 90.3% of patients with endometriod adenocarcinoma. The solid parts were slightly hyperintense on T2W images in 19 patients with marked enhancement after contrast administration. No significant difference (P0.13) in conventional MRI features was found between endometrioid adenocarcinoma and other malignant ovarian tumors. Hyperintensity on DWI was more frequently observed in malignant tumors than in benign lesions (P<0.001). ADC values were significantly lower in endometrioid adenocarcinoma than other malignant tumors (0.79=0.21 vs. 0.90=0.19; P0.04) and in all malignant lesions compared with benign tumors (0.88=0.31 vs. 1.33=0.17; P<0.001). Conclusion: DWI with ADC measurement could indicate the presence of endometrioid adenocarcinomas due to a slightly but significantly lower ADC values compared to other malignant ovarian lesions. Thus, DWI is beneficial and should be part of a standard protocol for the evaluation of indeterminate adnexal lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 758-766 |
| Number of pages | 9 |
| Journal | Acta Radiologica |
| Volume | 57 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
| Externally published | Yes |
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Keywords
- Diffusion-weighted imaging (DWI)
- Endometrioid adenocarcinoma
- Magnetic resonance imaging (MRI)
- Ovarian tumors
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
Cite this
Endometrioid adenocarcinoma of the ovary : MRI findings with emphasis on diffusion-weighted imaging for the differentiation of ovarian tumors. / Kovac, Jelena Djokic; Terzić, Milan; Mirković, Milan; Banko, Bojan; Dikić-Rom, Aleksandra; Maksimović, Ruzica.
In: Acta Radiologica, Vol. 57, No. 6, 01.01.2016, p. 758-766.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endometrioid adenocarcinoma of the ovary
T2 - MRI findings with emphasis on diffusion-weighted imaging for the differentiation of ovarian tumors
AU - Kovac, Jelena Djokic
AU - Terzić, Milan
AU - Mirković, Milan
AU - Banko, Bojan
AU - Dikić-Rom, Aleksandra
AU - Maksimović, Ruzica
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: Preoperative differentiation of ovarian malignant tumors still remains a challenge. Diffusion-weighted imaging (DWI) provides information about cellularity of the lesion and might facilitate discrimination between different malignant ovarian lesions. Purpose: To evaluate magnetic resonance imaging (MRI) findings of endometrioid adenocarcinoma of the ovary and to determine the value of DWI in the differential diagnosis of malignant and benign adnexal tumors. Material and Methods: The following MRI findings were reviewed in 162 patients (21 endometrioid adenocarcinoma, 103 other malignant tumors, 38 benign tumors): lesion size, morphological appearance, T2-weighted (T2W) signal intensity, T1-weighted (T1W) signal intensity, contrast-enhancement pattern, DWI signals with apparent diffusion coefficient (ADC) calculated for b800 s/mm2 in solid tumor components. Results: The most common morphological appearance was predominantly cystic lesion, found in 90.3% of patients with endometriod adenocarcinoma. The solid parts were slightly hyperintense on T2W images in 19 patients with marked enhancement after contrast administration. No significant difference (P0.13) in conventional MRI features was found between endometrioid adenocarcinoma and other malignant ovarian tumors. Hyperintensity on DWI was more frequently observed in malignant tumors than in benign lesions (P<0.001). ADC values were significantly lower in endometrioid adenocarcinoma than other malignant tumors (0.79=0.21 vs. 0.90=0.19; P0.04) and in all malignant lesions compared with benign tumors (0.88=0.31 vs. 1.33=0.17; P<0.001). Conclusion: DWI with ADC measurement could indicate the presence of endometrioid adenocarcinomas due to a slightly but significantly lower ADC values compared to other malignant ovarian lesions. Thus, DWI is beneficial and should be part of a standard protocol for the evaluation of indeterminate adnexal lesions.
AB - Background: Preoperative differentiation of ovarian malignant tumors still remains a challenge. Diffusion-weighted imaging (DWI) provides information about cellularity of the lesion and might facilitate discrimination between different malignant ovarian lesions. Purpose: To evaluate magnetic resonance imaging (MRI) findings of endometrioid adenocarcinoma of the ovary and to determine the value of DWI in the differential diagnosis of malignant and benign adnexal tumors. Material and Methods: The following MRI findings were reviewed in 162 patients (21 endometrioid adenocarcinoma, 103 other malignant tumors, 38 benign tumors): lesion size, morphological appearance, T2-weighted (T2W) signal intensity, T1-weighted (T1W) signal intensity, contrast-enhancement pattern, DWI signals with apparent diffusion coefficient (ADC) calculated for b800 s/mm2 in solid tumor components. Results: The most common morphological appearance was predominantly cystic lesion, found in 90.3% of patients with endometriod adenocarcinoma. The solid parts were slightly hyperintense on T2W images in 19 patients with marked enhancement after contrast administration. No significant difference (P0.13) in conventional MRI features was found between endometrioid adenocarcinoma and other malignant ovarian tumors. Hyperintensity on DWI was more frequently observed in malignant tumors than in benign lesions (P<0.001). ADC values were significantly lower in endometrioid adenocarcinoma than other malignant tumors (0.79=0.21 vs. 0.90=0.19; P0.04) and in all malignant lesions compared with benign tumors (0.88=0.31 vs. 1.33=0.17; P<0.001). Conclusion: DWI with ADC measurement could indicate the presence of endometrioid adenocarcinomas due to a slightly but significantly lower ADC values compared to other malignant ovarian lesions. Thus, DWI is beneficial and should be part of a standard protocol for the evaluation of indeterminate adnexal lesions.
KW - Diffusion-weighted imaging (DWI)
KW - Endometrioid adenocarcinoma
KW - Magnetic resonance imaging (MRI)
KW - Ovarian tumors
UR - http://www.scopus.com/inward/record.url?scp=84978701076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978701076&partnerID=8YFLogxK
U2 - 10.1177/0284185115599805
DO - 10.1177/0284185115599805
M3 - Article
C2 - 26307063
AN - SCOPUS:84978701076
VL - 57
SP - 758
EP - 766
JO - Acta Radiologica
JF - Acta Radiologica
SN - 0284-1851
IS - 6
ER -