Enhanced antibacterial activity of rifampicin associated with biodegradable polybutylcyanoacrylate nanoparticles

I. N. Skidan, S. E. Gelperina, S. E. Severin, A. E. Gulyaev

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Association of rifampicin with polybutylcyanoacrylate nanoparticles provided considerable enhancement of drug antibacterial activity. In vitro nanoparticle-loaded rifampicin was more active against Staphylococcus aureus and Mycobacterium avium, localized in isolated alveolar macrophages. Level of rifampicin in macrophages increased 2-3-fold after incubation with rifampicin-loaded nanoparticles comparing to the free drug. High therapeutic efficacy of colloidal rifampicin was demonstrated in vivo. Use of nanoparticles provided 2-fold increase in rifampicin efficacy, comparing with the free drug at treatment of staphylococcus sepsis in mice. Single administration of nanoparticulate rifampicin in the dose 25 mg/kg resulted in 80% survival of mice with salmonellosis, while 50 mg/kg of free rifampicin could provide only 10% survival. It may be considered that high antibacterial efficacy of rifampicin bound to nanoparticles is due to its effective delivery to macrophages.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalAntibiotiki i Khimioterapiya
Issue number1
Publication statusPublished - Dec 1 2003


  • Alveolar macrophages
  • Antibacterial activity
  • Nanoparticles
  • Rifampicin

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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