Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments

Elizaveta Vinogradova; Zharkyn Jarmukhanov; Madiyar Nurgaziyev; Alibek Kossumov; Ayaulym Nurgozhina; Nurislam Mukhanbetzhanov; Shynggys Sergazy; Laura Chulenabyeva; Argul Issilbayeva; Sholpan Askarova; Aiym Kaiyrlykyzy; Saule Rakhimova; Ulan Kozhamkulov; Ulykbek Kairov; Zhanagul Khassenbekova; Dinar Tarzhanova; Ainur Akilzhanova; Joseph H. Lee; Joseph Terwilliger; Aliya Sailybayeva; Makhabbat Bekbossynova; Zhaxybay Zhumadilov; Samat Kozhakhmetov; Almagul Kushugulova

doi:10.1016/j.heliyon.2025.e41969

Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments

Elizaveta Vinogradova, Zharkyn Jarmukhanov, Madiyar Nurgaziyev, Alibek Kossumov, Ayaulym Nurgozhina, Nurislam Mukhanbetzhanov, Shynggys Sergazy, Laura Chulenabyeva, Argul Issilbayeva, Sholpan Askarova, Aiym Kaiyrlykyzy, Saule Rakhimova, Ulan Kozhamkulov, Ulykbek Kairov, Zhanagul Khassenbekova, Dinar Tarzhanova, Ainur Akilzhanova, Joseph H. Lee, Joseph Terwilliger, Aliya SailybayevaMakhabbat Bekbossynova, Zhaxybay Zhumadilov, Samat Kozhakhmetov, Almagul Kushugulova

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects vitamin D metabolism, directing serum vitamin D (VitD) levels and memory impairmets. It was found that gut microbiome composition, characterized by an increase in the relative abundance of Enterococcus and correlated with vitamin D deficiency and, as consequence, with memory impairments. A key mechanism identified in the study was the differential utilization of short-chain fatty acids (SCFAs) produced by gut bacteria as substrates for synthesizing vitamin D3 precursor in the skin. This finding confirms a complex interplay between the gut microbiome, host metabolism, and cognitive health, highlighting the potential significance of targeting Enterococcus dysbiosis in future preventive and therapeutic strategies to address VitD deficiency-related memory impairments. These results underscore the importance of understanding and modulating gut microbiome composition to optimize VitD status and cognitive function.

Original language	English
Article number	e41969
Journal	Heliyon
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.heliyon.2025.e41969
Publication status	Published - Jan 30 2025

Keywords

Butyrate producers
Cognitive impairments
Enterococcus dysbiosis
Gut microbiome
Memory performance
Metabolites
Metagenomics
Short-chain fatty acids (SCFAs)
Vitamin D deficiency
Vitamin D receptor (VDR)

ASJC Scopus subject areas

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Vinogradova, E., Jarmukhanov, Z., Nurgaziyev, M., Kossumov, A., Nurgozhina, A., Mukhanbetzhanov, N., Sergazy, S., Chulenabyeva, L., Issilbayeva, A., Askarova, S., Kaiyrlykyzy, A., Rakhimova, S., Kozhamkulov, U., Kairov, U., Khassenbekova, Z., Tarzhanova, D., Akilzhanova, A., Lee, J. H., Terwilliger, J., ... Kushugulova, A. (2025). Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments. Heliyon, 11(2), Article e41969. https://doi.org/10.1016/j.heliyon.2025.e41969

Vinogradova, E, Jarmukhanov, Z, Nurgaziyev, M, Kossumov, A , Nurgozhina, A, Mukhanbetzhanov, N, Sergazy, S, Chulenabyeva, L, Issilbayeva, A, Askarova, S , Kaiyrlykyzy, A , Rakhimova, S , Kozhamkulov, U , Kairov, U, Khassenbekova, Z, Tarzhanova, D, Akilzhanova, A, Lee, JH, Terwilliger, J, Sailybayeva, A, Bekbossynova, M, Zhumadilov, Z , Kozhakhmetov, S & Kushugulova, A 2025, 'Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments', Heliyon, vol. 11, no. 2, e41969. https://doi.org/10.1016/j.heliyon.2025.e41969

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title = "Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments",

abstract = "Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects vitamin D metabolism, directing serum vitamin D (VitD) levels and memory impairmets. It was found that gut microbiome composition, characterized by an increase in the relative abundance of Enterococcus and correlated with vitamin D deficiency and, as consequence, with memory impairments. A key mechanism identified in the study was the differential utilization of short-chain fatty acids (SCFAs) produced by gut bacteria as substrates for synthesizing vitamin D3 precursor in the skin. This finding confirms a complex interplay between the gut microbiome, host metabolism, and cognitive health, highlighting the potential significance of targeting Enterococcus dysbiosis in future preventive and therapeutic strategies to address VitD deficiency-related memory impairments. These results underscore the importance of understanding and modulating gut microbiome composition to optimize VitD status and cognitive function.",

keywords = "Butyrate producers, Cognitive impairments, Enterococcus dysbiosis, Gut microbiome, Memory performance, Metabolites, Metagenomics, Short-chain fatty acids (SCFAs), Vitamin D deficiency, Vitamin D receptor (VDR)",

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T1 - Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments

AU - Vinogradova, Elizaveta

AU - Jarmukhanov, Zharkyn

AU - Nurgaziyev, Madiyar

AU - Kossumov, Alibek

AU - Nurgozhina, Ayaulym

AU - Mukhanbetzhanov, Nurislam

AU - Sergazy, Shynggys

AU - Chulenabyeva, Laura

AU - Issilbayeva, Argul

AU - Askarova, Sholpan

AU - Kaiyrlykyzy, Aiym

AU - Rakhimova, Saule

AU - Kozhamkulov, Ulan

AU - Kairov, Ulykbek

AU - Khassenbekova, Zhanagul

AU - Tarzhanova, Dinar

AU - Akilzhanova, Ainur

AU - Lee, Joseph H.

AU - Terwilliger, Joseph

AU - Sailybayeva, Aliya

AU - Bekbossynova, Makhabbat

AU - Zhumadilov, Zhaxybay

AU - Kozhakhmetov, Samat

AU - Kushugulova, Almagul

PY - 2025/1/30

Y1 - 2025/1/30

N2 - Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects vitamin D metabolism, directing serum vitamin D (VitD) levels and memory impairmets. It was found that gut microbiome composition, characterized by an increase in the relative abundance of Enterococcus and correlated with vitamin D deficiency and, as consequence, with memory impairments. A key mechanism identified in the study was the differential utilization of short-chain fatty acids (SCFAs) produced by gut bacteria as substrates for synthesizing vitamin D3 precursor in the skin. This finding confirms a complex interplay between the gut microbiome, host metabolism, and cognitive health, highlighting the potential significance of targeting Enterococcus dysbiosis in future preventive and therapeutic strategies to address VitD deficiency-related memory impairments. These results underscore the importance of understanding and modulating gut microbiome composition to optimize VitD status and cognitive function.

AB - Low vitamin D status is linked to disturbance in cognitive performance. This study explored possible ways how composition and functional capacity of the gut microbiome affects vitamin D metabolism, directing serum vitamin D (VitD) levels and memory impairmets. It was found that gut microbiome composition, characterized by an increase in the relative abundance of Enterococcus and correlated with vitamin D deficiency and, as consequence, with memory impairments. A key mechanism identified in the study was the differential utilization of short-chain fatty acids (SCFAs) produced by gut bacteria as substrates for synthesizing vitamin D3 precursor in the skin. This finding confirms a complex interplay between the gut microbiome, host metabolism, and cognitive health, highlighting the potential significance of targeting Enterococcus dysbiosis in future preventive and therapeutic strategies to address VitD deficiency-related memory impairments. These results underscore the importance of understanding and modulating gut microbiome composition to optimize VitD status and cognitive function.

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KW - Cognitive impairments

KW - Enterococcus dysbiosis

KW - Gut microbiome

KW - Memory performance

KW - Metabolites

KW - Metagenomics

KW - Short-chain fatty acids (SCFAs)

KW - Vitamin D deficiency

KW - Vitamin D receptor (VDR)

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JO - Heliyon

JF - Heliyon

IS - 2

M1 - e41969

ER -

Enterococcus dysbiosis as a mediator of vitamin D deficiency-associated memory impairments

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