Abstract
The wiring of the nervous system arises from extensive directional migration of neuronal cell bodies and growth of processes that, somehow, end up forming functional circuits. Thus far, this feat of biological engineering appears to rely on sequences of pathfinding decisions upon local cues, each with little relationship to the anatomical and physiological outcome. Here, we uncover a straightforward cellular mechanism for circuit building whereby a neuronal type directs the development of its future partners. We show that visceral afferents of the head (that innervate taste buds) provide a scaffold for the establishment of visceral efferents (that innervate salivatory glandsandbloodvessels). Inembryological terms, sensory neurons derived from an epibranchial placode-that we show to develop largely independently from the neural crest-guide the directional outgrowth of hindbrain visceral motoneurons and control the formation of neural crest-derived parasympathetic ganglia.
| Original language | English |
|---|---|
| Pages (from-to) | 2066-2071 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 107 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Feb 2 2010 |
| Externally published | Yes |
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Keywords
- Autonomic nervous system
- Epibranchial placode
- Neural circuit
- Neural crest
- Phox2b
ASJC Scopus subject areas
- General
Cite this
Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. / Coppola, Eva; Rallu, Murielle; Richard, Juliette; Dufour, Sylvie; Riethmacher, Dieter; Guillemot, François; Goridis, Christo; Brunet, Jean François.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 5, 02.02.2010, p. 2066-2071.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Epibranchial ganglia orchestrate the development of the cranial neurogenic crest
AU - Coppola, Eva
AU - Rallu, Murielle
AU - Richard, Juliette
AU - Dufour, Sylvie
AU - Riethmacher, Dieter
AU - Guillemot, François
AU - Goridis, Christo
AU - Brunet, Jean François
PY - 2010/2/2
Y1 - 2010/2/2
N2 - The wiring of the nervous system arises from extensive directional migration of neuronal cell bodies and growth of processes that, somehow, end up forming functional circuits. Thus far, this feat of biological engineering appears to rely on sequences of pathfinding decisions upon local cues, each with little relationship to the anatomical and physiological outcome. Here, we uncover a straightforward cellular mechanism for circuit building whereby a neuronal type directs the development of its future partners. We show that visceral afferents of the head (that innervate taste buds) provide a scaffold for the establishment of visceral efferents (that innervate salivatory glandsandbloodvessels). Inembryological terms, sensory neurons derived from an epibranchial placode-that we show to develop largely independently from the neural crest-guide the directional outgrowth of hindbrain visceral motoneurons and control the formation of neural crest-derived parasympathetic ganglia.
AB - The wiring of the nervous system arises from extensive directional migration of neuronal cell bodies and growth of processes that, somehow, end up forming functional circuits. Thus far, this feat of biological engineering appears to rely on sequences of pathfinding decisions upon local cues, each with little relationship to the anatomical and physiological outcome. Here, we uncover a straightforward cellular mechanism for circuit building whereby a neuronal type directs the development of its future partners. We show that visceral afferents of the head (that innervate taste buds) provide a scaffold for the establishment of visceral efferents (that innervate salivatory glandsandbloodvessels). Inembryological terms, sensory neurons derived from an epibranchial placode-that we show to develop largely independently from the neural crest-guide the directional outgrowth of hindbrain visceral motoneurons and control the formation of neural crest-derived parasympathetic ganglia.
KW - Autonomic nervous system
KW - Epibranchial placode
KW - Neural circuit
KW - Neural crest
KW - Phox2b
UR - http://www.scopus.com/inward/record.url?scp=76649122536&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76649122536&partnerID=8YFLogxK
U2 - 10.1073/pnas.0910213107
DO - 10.1073/pnas.0910213107
M3 - Article
VL - 107
SP - 2066
EP - 2071
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 5
ER -