Epibranchial ganglia orchestrate the development of the cranial neurogenic crest

Eva Coppola, Murielle Rallu, Juliette Richard, Sylvie Dufour, Dieter Riethmacher, François Guillemot, Christo Goridis, Jean François Brunet

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The wiring of the nervous system arises from extensive directional migration of neuronal cell bodies and growth of processes that, somehow, end up forming functional circuits. Thus far, this feat of biological engineering appears to rely on sequences of pathfinding decisions upon local cues, each with little relationship to the anatomical and physiological outcome. Here, we uncover a straightforward cellular mechanism for circuit building whereby a neuronal type directs the development of its future partners. We show that visceral afferents of the head (that innervate taste buds) provide a scaffold for the establishment of visceral efferents (that innervate salivatory glandsandbloodvessels). Inembryological terms, sensory neurons derived from an epibranchial placode-that we show to develop largely independently from the neural crest-guide the directional outgrowth of hindbrain visceral motoneurons and control the formation of neural crest-derived parasympathetic ganglia.

Original languageEnglish
Pages (from-to)2066-2071
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number5
DOIs
Publication statusPublished - Feb 2 2010
Externally publishedYes

Fingerprint

Neural Crest
Ganglia
Cell Growth Processes
Parasympathetic Ganglia
Visceral Afferents
Taste Buds
Bioengineering
Rhombencephalon
Motor Neurons
Sensory Receptor Cells
Nervous System
Cues
Head
Cell Body

Keywords

  • Autonomic nervous system
  • Epibranchial placode
  • Neural circuit
  • Neural crest
  • Phox2b

ASJC Scopus subject areas

  • General

Cite this

Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. / Coppola, Eva; Rallu, Murielle; Richard, Juliette; Dufour, Sylvie; Riethmacher, Dieter; Guillemot, François; Goridis, Christo; Brunet, Jean François.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 5, 02.02.2010, p. 2066-2071.

Research output: Contribution to journalArticle

Coppola, Eva ; Rallu, Murielle ; Richard, Juliette ; Dufour, Sylvie ; Riethmacher, Dieter ; Guillemot, François ; Goridis, Christo ; Brunet, Jean François. / Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. In: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Vol. 107, No. 5. pp. 2066-2071.
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