Epidemiology of dialysis-treated end-stage renal disease patients in Kazakhstan: data from nationwide large-scale registry 2014-2018

Abduzhappar Gaipov; Alpamys Issanov; Kainar Kadyrzhanuly; Dinara Galiyeva; Marina Khvan; Mohamad Aljofan; Miklos Z Molnar; Csaba P Kovesdy

doi:10.1186/s12882-020-02047-6

Epidemiology of dialysis-treated end-stage renal disease patients in Kazakhstan: data from nationwide large-scale registry 2014-2018

Abduzhappar Gaipov
, Alpamys Issanov
, Kainar Kadyrzhanuly
, Dinara Galiyeva
, Marina Khvan
, Mohamad Aljofan
, Miklos Z Molnar
, Csaba P Kovesdy

Nazarbayev University
City Hospital №1, Nur-Sultan
University of Tennessee Health Science Center

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

BACKGROUND: The epidemiology of dialysis patients has been little studied in developing countries and economies in transition. We examined the prevalence, incidence and mortality rate of dialysis patients in Kazakhstan, via aggregation and utilization of large-scale administrative healthcare data.

METHODS: The registry data of 8898 patients receiving dialysis therapy between 2014 and 2018 years were extracted from the Unified National Electronic Health System (UNEHS) and linked with the national population registry of Kazakhstan. We provide descriptive statistics of demographic, comorbidity and dialysis-related characteristics.

RESULTS: Among all patients undergoing maintenance dialysis for end-stage renal disease (ESRD), there were 3941 (44%) females and 4957 (56%) males. 98.7% of patients received hemodialysis and 1.3% peritoneal dialysis. The majority of the patients (63%) were ethnic Kazakhs, 18% were Russians and 19% were of other ethnicities. The prevalence and incidence rate in 2014 were 135.2 and 68.9 per million population (PMP), respectively, which were different in 2018 [350.2 and 94.9 PMP, respectively]. Overall mortality rate among dialysis patients reduced from 1667/1000 patient-years [95%Confidence Interval (CI): 1473-1886] (PY) in 2014 to 710/1000PY [95%CI: 658-767] in 2018. We observed 13% lower crude survival probability in females compared to males and in older patients compared to younger ones. Russian ethnicity had 58% higher risk of death, while other ethnicities had 34% higher risk of death compared to in those of Kazakh ethnicity.

CONCLUSION: We describe for the first time in Kazakhstan an increase in the prevalence and incidence of ESRD on dialysis, while mortality rate decreased over time, during 2014-2018. We observed statistically significant lower survival probability in female dialysis patients compared to males, in older patients compared to younger ones, and in patients of Russian ethnicity compared to Kazakh.

Original language	English
Article number	407
Pages (from-to)	407
Journal	BMC Nephrology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12882-020-02047-6
Publication status	Published - Sept 21 2020

Funding

This study was supported by grants from the Nazarbayev University Faculty Development Research Grant Program FDCRGP 2020-2022 (Funder Project Reference: 240919FD3913, title: Aggregation and utilization of the large-scale administrative health data in Kazakhstan for population health research and surveillance). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. A.G. is a PI of the project.

Funders	Funder number
Nazarbayev University	FDCRGP 2020-2022, 240919FD3913

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 4 Quality Education
SDG 5 Gender Equality
SDG 16 Peace, Justice and Strong Institutions

Keywords

Dialysis
Epidemiology
ESRD
Kazakhstan
Registry

ASJC Scopus subject areas

Nephrology

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10.1186/s12882-020-02047-6

Cite this

@article{172234758b194fb5890624010cbd9e87,

title = "Epidemiology of dialysis-treated end-stage renal disease patients in Kazakhstan: data from nationwide large-scale registry 2014-2018",

abstract = "BACKGROUND: The epidemiology of dialysis patients has been little studied in developing countries and economies in transition. We examined the prevalence, incidence and mortality rate of dialysis patients in Kazakhstan, via aggregation and utilization of large-scale administrative healthcare data.METHODS: The registry data of 8898 patients receiving dialysis therapy between 2014 and 2018 years were extracted from the Unified National Electronic Health System (UNEHS) and linked with the national population registry of Kazakhstan. We provide descriptive statistics of demographic, comorbidity and dialysis-related characteristics.RESULTS: Among all patients undergoing maintenance dialysis for end-stage renal disease (ESRD), there were 3941 (44\%) females and 4957 (56\%) males. 98.7\% of patients received hemodialysis and 1.3\% peritoneal dialysis. The majority of the patients (63\%) were ethnic Kazakhs, 18\% were Russians and 19\% were of other ethnicities. The prevalence and incidence rate in 2014 were 135.2 and 68.9 per million population (PMP), respectively, which were different in 2018 [350.2 and 94.9 PMP, respectively]. Overall mortality rate among dialysis patients reduced from 1667/1000 patient-years [95\%Confidence Interval (CI): 1473-1886] (PY) in 2014 to 710/1000PY [95\%CI: 658-767] in 2018. We observed 13\% lower crude survival probability in females compared to males and in older patients compared to younger ones. Russian ethnicity had 58\% higher risk of death, while other ethnicities had 34\% higher risk of death compared to in those of Kazakh ethnicity.CONCLUSION: We describe for the first time in Kazakhstan an increase in the prevalence and incidence of ESRD on dialysis, while mortality rate decreased over time, during 2014-2018. We observed statistically significant lower survival probability in female dialysis patients compared to males, in older patients compared to younger ones, and in patients of Russian ethnicity compared to Kazakh.",

keywords = "Dialysis, Epidemiology, ESRD, Kazakhstan, Registry",

author = "Abduzhappar Gaipov and Alpamys Issanov and Kainar Kadyrzhanuly and Dinara Galiyeva and Marina Khvan and Mohamad Aljofan and Molnar, \{Miklos Z\} and Kovesdy, \{Csaba P\}",

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doi = "10.1186/s12882-020-02047-6",

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TY - JOUR

T1 - Epidemiology of dialysis-treated end-stage renal disease patients in Kazakhstan

T2 - data from nationwide large-scale registry 2014-2018

AU - Gaipov, Abduzhappar

AU - Issanov, Alpamys

AU - Kadyrzhanuly, Kainar

AU - Galiyeva, Dinara

AU - Khvan, Marina

AU - Aljofan, Mohamad

AU - Molnar, Miklos Z

AU - Kovesdy, Csaba P

PY - 2020/9/21

Y1 - 2020/9/21

N2 - BACKGROUND: The epidemiology of dialysis patients has been little studied in developing countries and economies in transition. We examined the prevalence, incidence and mortality rate of dialysis patients in Kazakhstan, via aggregation and utilization of large-scale administrative healthcare data.METHODS: The registry data of 8898 patients receiving dialysis therapy between 2014 and 2018 years were extracted from the Unified National Electronic Health System (UNEHS) and linked with the national population registry of Kazakhstan. We provide descriptive statistics of demographic, comorbidity and dialysis-related characteristics.RESULTS: Among all patients undergoing maintenance dialysis for end-stage renal disease (ESRD), there were 3941 (44%) females and 4957 (56%) males. 98.7% of patients received hemodialysis and 1.3% peritoneal dialysis. The majority of the patients (63%) were ethnic Kazakhs, 18% were Russians and 19% were of other ethnicities. The prevalence and incidence rate in 2014 were 135.2 and 68.9 per million population (PMP), respectively, which were different in 2018 [350.2 and 94.9 PMP, respectively]. Overall mortality rate among dialysis patients reduced from 1667/1000 patient-years [95%Confidence Interval (CI): 1473-1886] (PY) in 2014 to 710/1000PY [95%CI: 658-767] in 2018. We observed 13% lower crude survival probability in females compared to males and in older patients compared to younger ones. Russian ethnicity had 58% higher risk of death, while other ethnicities had 34% higher risk of death compared to in those of Kazakh ethnicity.CONCLUSION: We describe for the first time in Kazakhstan an increase in the prevalence and incidence of ESRD on dialysis, while mortality rate decreased over time, during 2014-2018. We observed statistically significant lower survival probability in female dialysis patients compared to males, in older patients compared to younger ones, and in patients of Russian ethnicity compared to Kazakh.

AB - BACKGROUND: The epidemiology of dialysis patients has been little studied in developing countries and economies in transition. We examined the prevalence, incidence and mortality rate of dialysis patients in Kazakhstan, via aggregation and utilization of large-scale administrative healthcare data.METHODS: The registry data of 8898 patients receiving dialysis therapy between 2014 and 2018 years were extracted from the Unified National Electronic Health System (UNEHS) and linked with the national population registry of Kazakhstan. We provide descriptive statistics of demographic, comorbidity and dialysis-related characteristics.RESULTS: Among all patients undergoing maintenance dialysis for end-stage renal disease (ESRD), there were 3941 (44%) females and 4957 (56%) males. 98.7% of patients received hemodialysis and 1.3% peritoneal dialysis. The majority of the patients (63%) were ethnic Kazakhs, 18% were Russians and 19% were of other ethnicities. The prevalence and incidence rate in 2014 were 135.2 and 68.9 per million population (PMP), respectively, which were different in 2018 [350.2 and 94.9 PMP, respectively]. Overall mortality rate among dialysis patients reduced from 1667/1000 patient-years [95%Confidence Interval (CI): 1473-1886] (PY) in 2014 to 710/1000PY [95%CI: 658-767] in 2018. We observed 13% lower crude survival probability in females compared to males and in older patients compared to younger ones. Russian ethnicity had 58% higher risk of death, while other ethnicities had 34% higher risk of death compared to in those of Kazakh ethnicity.CONCLUSION: We describe for the first time in Kazakhstan an increase in the prevalence and incidence of ESRD on dialysis, while mortality rate decreased over time, during 2014-2018. We observed statistically significant lower survival probability in female dialysis patients compared to males, in older patients compared to younger ones, and in patients of Russian ethnicity compared to Kazakh.

KW - Dialysis

KW - Epidemiology

KW - ESRD

KW - Kazakhstan

KW - Registry

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UR - https://www.scopus.com/pages/publications/85091475646#tab=citedBy

U2 - 10.1186/s12882-020-02047-6

DO - 10.1186/s12882-020-02047-6

M3 - Article

C2 - 32957909

SN - 1471-2369

VL - 21

SP - 407

JO - BMC Nephrology

JF - BMC Nephrology

IS - 1

M1 - 407

ER -

Epidemiology of dialysis-treated end-stage renal disease patients in Kazakhstan: data from nationwide large-scale registry 2014-2018

Abstract

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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