Epithelial sodium channel in planar lipid bilayers.

Bakhrom K. Berdiev, Dale J. Benos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Amiloride-sensitive Na+ channels belong to the epithelial Na+ channel (ENaC)-degenerin superfamily of ion channels. In addition to their key role in sodium handling, they serve diverse functions in many tissues. Improper functioning of ENaC has been implicated in several diseases, including salt-sensitive hypertension (Liddle's syndrome), salt-wasting syndrome (pseudohypoaldosteronism type I), pulmonary edema, and cystic fibrosis. We have utilized planar lipid bilayers, a well-defined system that allows simultaneous control of "internal" and "external" solutions, to study ENaCs.

Original languageEnglish
Pages (from-to)89-99
Number of pages11
JournalMethods in molecular biology (Clifton, N.J.)
Volume337
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

Epithelial Sodium Channels
Lipid Bilayers
Degenerin Sodium Channels
Liddle Syndrome
Pseudohypoaldosteronism
Salts
Wasting Syndrome
Internal-External Control
Amiloride
Pulmonary Edema
Cystic Fibrosis
Sodium
Hypertension
Handling (Psychology)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Epithelial sodium channel in planar lipid bilayers. / Berdiev, Bakhrom K.; Benos, Dale J.

In: Methods in molecular biology (Clifton, N.J.), Vol. 337, 2006, p. 89-99.

Research output: Contribution to journalArticle

Berdiev, Bakhrom K. ; Benos, Dale J. / Epithelial sodium channel in planar lipid bilayers. In: Methods in molecular biology (Clifton, N.J.). 2006 ; Vol. 337. pp. 89-99.
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