Epitope predictions

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract

Epitopes or antigenic determinants are regions of proteins that can trigger a cellular immune response mediated by T or B cells. T cell epitopes are usually protein antigen-derived peptides presented by MHC molecules on antigen-presenting cells and recognized by T-cell receptors. B cell epitopes are either peptides or protein surface residues that bind to an antibody. Since epitopes are central to vaccine design, infectious disease prevention, disease diagnosis and treatment we discuss and analyze computational approaches to predict epitopes. Epitope prediction reduces time and cost to arrive from a protein sequence at a vaccine, diagnostic or therapeutic peptide or protein.
Original languageEnglish
Title of host publicationEncyclopedia of Bioinformatics and Computational Biology
Subtitle of host publicationABC of Bioinformatics
EditorsShoba Ranganathan, Michael Gribskov, Kenta Nakai, Christian Schönbach
PublisherElsevier
Pages952
Number of pages971
Volume2
Edition1
ISBN (Electronic)9780128114322
ISBN (Print)9780128114148
DOIs
Publication statusPublished - Jan 1 2019

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