Error of a temperature probe for cancer ablation monitoring caused by respiratory movements

Ex vivo and in vivo analysis

Camilla Cavaiola, Paola Saccomandi, Carlo Massaroni, Daniele Tosi, Francesco Giurazza, Giulia Frauenfelder, Bruno Beomonte Zobel, Francesco Maria Di Matteo, Michele Arturo Caponero, Andrea Polimadei, Emiliano Schena

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Hyperthermal techniques are spreading as an alternative to conventional surgery for cancer removal. A real-time temperature feedback can be used to adjust the treatment settings, in order to improve the clinical outcomes. In this paper, we experimentally assessed the feasibility for distributed temperature monitoring of a custom probe, which consists of a needle embedding six fiber Bragg gratings (FBGs). Since FBGs are also sensitive to strain, we focused on the analysis of the measurement error (artifact) caused by respiratory movements. We assessed the artifact both on ex vivo pig liver and lung (by mimicking the movement of these organs caused by respiration) and on in vivo trial on pig liver. Lastly, we proposed an algorithm to detect and minimize the artifact during ex vivo liver laser ablation. During both ex vivo and in vivo trials, the probe insertion within the organ was easy and safe. The artifact was significant (up to 3 °C), but the correction algorithm allows minimizing the error. The main advantages of the proposed probe are: 1) spatially resolved temperature monitoring (in six points of the tissue by inserting a single needle) and 2) the needle is magnetic resonance (MR)-compatible, hence can be used during MR-guided procedure. Even if the model is close to humans, further trials are required to investigate the feasibility of the probe for clinical applications.

Original languageEnglish
Article number7482660
Pages (from-to)5934-5941
Number of pages8
JournalIEEE Sensors Journal
Volume16
Issue number15
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

temperature probes
Ablation
ablation
artifacts
cancer
liver
needles
Liver
Needles
swine
Monitoring
probes
Fiber Bragg gratings
Magnetic resonance
organs
Bragg gratings
magnetic resonance
Temperature
fibers
respiration

Keywords

  • Cancer ablation
  • fiber Bragg grating sensors
  • fiber optic sensors
  • respiratory movements
  • temperature measurements

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Instrumentation

Cite this

Cavaiola, C., Saccomandi, P., Massaroni, C., Tosi, D., Giurazza, F., Frauenfelder, G., ... Schena, E. (2016). Error of a temperature probe for cancer ablation monitoring caused by respiratory movements: Ex vivo and in vivo analysis. IEEE Sensors Journal, 16(15), 5934-5941. [7482660]. https://doi.org/10.1109/JSEN.2016.2574959

Error of a temperature probe for cancer ablation monitoring caused by respiratory movements : Ex vivo and in vivo analysis. / Cavaiola, Camilla; Saccomandi, Paola; Massaroni, Carlo; Tosi, Daniele; Giurazza, Francesco; Frauenfelder, Giulia; Beomonte Zobel, Bruno; Di Matteo, Francesco Maria; Caponero, Michele Arturo; Polimadei, Andrea; Schena, Emiliano.

In: IEEE Sensors Journal, Vol. 16, No. 15, 7482660, 01.08.2016, p. 5934-5941.

Research output: Contribution to journalArticle

Cavaiola, C, Saccomandi, P, Massaroni, C, Tosi, D, Giurazza, F, Frauenfelder, G, Beomonte Zobel, B, Di Matteo, FM, Caponero, MA, Polimadei, A & Schena, E 2016, 'Error of a temperature probe for cancer ablation monitoring caused by respiratory movements: Ex vivo and in vivo analysis', IEEE Sensors Journal, vol. 16, no. 15, 7482660, pp. 5934-5941. https://doi.org/10.1109/JSEN.2016.2574959
Cavaiola, Camilla ; Saccomandi, Paola ; Massaroni, Carlo ; Tosi, Daniele ; Giurazza, Francesco ; Frauenfelder, Giulia ; Beomonte Zobel, Bruno ; Di Matteo, Francesco Maria ; Caponero, Michele Arturo ; Polimadei, Andrea ; Schena, Emiliano. / Error of a temperature probe for cancer ablation monitoring caused by respiratory movements : Ex vivo and in vivo analysis. In: IEEE Sensors Journal. 2016 ; Vol. 16, No. 15. pp. 5934-5941.
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