Abstract
Hyperthermal techniques are spreading as an alternative to conventional surgery for cancer removal. A real-time temperature feedback can be used to adjust the treatment settings, in order to improve the clinical outcomes. In this paper, we experimentally assessed the feasibility for distributed temperature monitoring of a custom probe, which consists of a needle embedding six fiber Bragg gratings (FBGs). Since FBGs are also sensitive to strain, we focused on the analysis of the measurement error (artifact) caused by respiratory movements. We assessed the artifact both on ex vivo pig liver and lung (by mimicking the movement of these organs caused by respiration) and on in vivo trial on pig liver. Lastly, we proposed an algorithm to detect and minimize the artifact during ex vivo liver laser ablation. During both ex vivo and in vivo trials, the probe insertion within the organ was easy and safe. The artifact was significant (up to 3 °C), but the correction algorithm allows minimizing the error. The main advantages of the proposed probe are: 1) spatially resolved temperature monitoring (in six points of the tissue by inserting a single needle) and 2) the needle is magnetic resonance (MR)-compatible, hence can be used during MR-guided procedure. Even if the model is close to humans, further trials are required to investigate the feasibility of the probe for clinical applications.
| Original language | English |
|---|---|
| Article number | 7482660 |
| Pages (from-to) | 5934-5941 |
| Number of pages | 8 |
| Journal | IEEE Sensors Journal |
| Volume | 16 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - Aug 1 2016 |
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Keywords
- Cancer ablation
- fiber Bragg grating sensors
- fiber optic sensors
- respiratory movements
- temperature measurements
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Instrumentation
Cite this
Error of a temperature probe for cancer ablation monitoring caused by respiratory movements : Ex vivo and in vivo analysis. / Cavaiola, Camilla; Saccomandi, Paola; Massaroni, Carlo; Tosi, Daniele; Giurazza, Francesco; Frauenfelder, Giulia; Beomonte Zobel, Bruno; Di Matteo, Francesco Maria; Caponero, Michele Arturo; Polimadei, Andrea; Schena, Emiliano.
In: IEEE Sensors Journal, Vol. 16, No. 15, 7482660, 01.08.2016, p. 5934-5941.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Error of a temperature probe for cancer ablation monitoring caused by respiratory movements
T2 - Ex vivo and in vivo analysis
AU - Cavaiola, Camilla
AU - Saccomandi, Paola
AU - Massaroni, Carlo
AU - Tosi, Daniele
AU - Giurazza, Francesco
AU - Frauenfelder, Giulia
AU - Beomonte Zobel, Bruno
AU - Di Matteo, Francesco Maria
AU - Caponero, Michele Arturo
AU - Polimadei, Andrea
AU - Schena, Emiliano
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Hyperthermal techniques are spreading as an alternative to conventional surgery for cancer removal. A real-time temperature feedback can be used to adjust the treatment settings, in order to improve the clinical outcomes. In this paper, we experimentally assessed the feasibility for distributed temperature monitoring of a custom probe, which consists of a needle embedding six fiber Bragg gratings (FBGs). Since FBGs are also sensitive to strain, we focused on the analysis of the measurement error (artifact) caused by respiratory movements. We assessed the artifact both on ex vivo pig liver and lung (by mimicking the movement of these organs caused by respiration) and on in vivo trial on pig liver. Lastly, we proposed an algorithm to detect and minimize the artifact during ex vivo liver laser ablation. During both ex vivo and in vivo trials, the probe insertion within the organ was easy and safe. The artifact was significant (up to 3 °C), but the correction algorithm allows minimizing the error. The main advantages of the proposed probe are: 1) spatially resolved temperature monitoring (in six points of the tissue by inserting a single needle) and 2) the needle is magnetic resonance (MR)-compatible, hence can be used during MR-guided procedure. Even if the model is close to humans, further trials are required to investigate the feasibility of the probe for clinical applications.
AB - Hyperthermal techniques are spreading as an alternative to conventional surgery for cancer removal. A real-time temperature feedback can be used to adjust the treatment settings, in order to improve the clinical outcomes. In this paper, we experimentally assessed the feasibility for distributed temperature monitoring of a custom probe, which consists of a needle embedding six fiber Bragg gratings (FBGs). Since FBGs are also sensitive to strain, we focused on the analysis of the measurement error (artifact) caused by respiratory movements. We assessed the artifact both on ex vivo pig liver and lung (by mimicking the movement of these organs caused by respiration) and on in vivo trial on pig liver. Lastly, we proposed an algorithm to detect and minimize the artifact during ex vivo liver laser ablation. During both ex vivo and in vivo trials, the probe insertion within the organ was easy and safe. The artifact was significant (up to 3 °C), but the correction algorithm allows minimizing the error. The main advantages of the proposed probe are: 1) spatially resolved temperature monitoring (in six points of the tissue by inserting a single needle) and 2) the needle is magnetic resonance (MR)-compatible, hence can be used during MR-guided procedure. Even if the model is close to humans, further trials are required to investigate the feasibility of the probe for clinical applications.
KW - Cancer ablation
KW - fiber Bragg grating sensors
KW - fiber optic sensors
KW - respiratory movements
KW - temperature measurements
UR - http://www.scopus.com/inward/record.url?scp=84978710304&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978710304&partnerID=8YFLogxK
U2 - 10.1109/JSEN.2016.2574959
DO - 10.1109/JSEN.2016.2574959
M3 - Article
VL - 16
SP - 5934
EP - 5941
JO - IEEE Sensors Journal
JF - IEEE Sensors Journal
SN - 1530-437X
IS - 15
M1 - 7482660
ER -