Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

Friedhelm Bladt, Dieter Riethmacher, Stefan Isenmann, Adriano Aguzzi, Carmen Birchmeier

Research output: Contribution to journalArticle

1025 Citations (Scopus)

Abstract

LIMB muscles develop from cells that migrate from the somites1,2. The signal that induces migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb bud2,3. Here we report that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and for migration into diaphragm and tip of tongue. In c-met homozygous mutant (-/-) mouse embryos, the limb bud and diaphragm are not colonized by myogenic precursor cells and, as a consequence, skeletal muscles of the limb and diaphragm do not form. In contrast, development of the axial skeletal muscles proceeds in the absence of c-met signalling. The specific ligand of the c-met protein, the motility and growth factor scatter factor/ hepatocyte growth factor4-9, is expressed in limb mesenchyme and can thus provide the signal for migration which is received by c-met. We have therefore identified a paracrine signalling system that regulates migration of myogenic precursor cells.

Original languageEnglish
Pages (from-to)768-771
Number of pages4
JournalNature
Volume376
Issue number6543
DOIs
Publication statusPublished - Jan 1 1995

ASJC Scopus subject areas

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