Estrogen receptor-α in the inhibition of cancer growth and angiogenesis

Syed Hamid Ali, Amy L. O’Donnell, Daya Balu, Mary B. Pohl, Marie J. Seyler, Seema Mohamed, Shaker Mousa, Paresh Dandona

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

A high level of estrogen receptor-α (ER-α) is believed to be favorable in the prognosis and treatment of certain female cancers. ER-α expression in the ER-negative breast cancer cell lines inhibits their proliferation and invasive, metastatic potential in vitro. We stably overexpressed the ER-α in the human endometrial cancer cell line Ishikawa and showed that, unlike estradiol, high levels of ER-α significantly inhibit the growth of tumors xenografted from the Ishikawa cells. Subsequent to ER-α overexpression, in vivo down-regulation of vascular endothelial growth factor was observed in tumor xenografts. In addition, these tumors showed an inhibition of vascularization and of the angiogenic agent, integrin αvβ3. Involvement of a switch in the angiogenic pathways during tumorigenesis has been a recent focus of interest. Our results indicate that a high level of ER-α may be beneficial in the control of female cancers because of its inhibitory effect on such angiogenic pathways.

Original languageEnglish
Pages (from-to)7094-7098
Number of pages5
JournalCancer Research
Volume60
Issue number24
Publication statusPublished - Dec 15 2000

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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