Estrogen receptor-α in the inhibition of cancer growth and angiogenesis

S. H. Ali, A. L. O'Donnell, D. Balu, M. B. Pohl, M. J. Seyler, S. Mohamed, S. Mousa, P. Dandona

Research output: Contribution to journalArticle

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Abstract

A high level of estrogen receptor-α (ER-α) is believed to be favorable in the prognosis and treatment of certain female cancers. ER-α expression in the ER-negative breast cancer cell lines inhibits their proliferation and invasive, metastatic potential in vitro. We stably overexpressed the ER-α in the human endometrial cancer cell line Ishikawa and showed that, unlike estradiol, high levels of ER-α significantly inhibit the growth of tumors xenografted from the Ishikawa cells. Subsequent to ER-α overexpression, in vivo down-regulation of vascular endothelial growth factor was observed in tumor xenografts. In addition, these tumors showed an inhibition of vascularization and of the angiogenic agent, integrin αvβ3. Involvement of a switch in the angiogenic pathways during tumorigenesis has been a recent focus of interest. Our results indicate that a high level of ER-α may be beneficial in the control of female cancers because of its inhibitory effect on such angiogenic pathways.

Original languageEnglish
Pages (from-to)7094-7098
Number of pages5
JournalCancer Research
Volume60
Issue number24
Publication statusPublished - Dec 15 2000
Externally publishedYes

Fingerprint

Estrogen Receptors
Growth
Neoplasms
Cell Line
Endometrial Neoplasms
Heterografts
Integrins
Vascular Endothelial Growth Factor A
Estradiol
Carcinogenesis
Down-Regulation
Breast Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ali, S. H., O'Donnell, A. L., Balu, D., Pohl, M. B., Seyler, M. J., Mohamed, S., ... Dandona, P. (2000). Estrogen receptor-α in the inhibition of cancer growth and angiogenesis. Cancer Research, 60(24), 7094-7098.

Estrogen receptor-α in the inhibition of cancer growth and angiogenesis. / Ali, S. H.; O'Donnell, A. L.; Balu, D.; Pohl, M. B.; Seyler, M. J.; Mohamed, S.; Mousa, S.; Dandona, P.

In: Cancer Research, Vol. 60, No. 24, 15.12.2000, p. 7094-7098.

Research output: Contribution to journalArticle

Ali, SH, O'Donnell, AL, Balu, D, Pohl, MB, Seyler, MJ, Mohamed, S, Mousa, S & Dandona, P 2000, 'Estrogen receptor-α in the inhibition of cancer growth and angiogenesis', Cancer Research, vol. 60, no. 24, pp. 7094-7098.
Ali SH, O'Donnell AL, Balu D, Pohl MB, Seyler MJ, Mohamed S et al. Estrogen receptor-α in the inhibition of cancer growth and angiogenesis. Cancer Research. 2000 Dec 15;60(24):7094-7098.
Ali, S. H. ; O'Donnell, A. L. ; Balu, D. ; Pohl, M. B. ; Seyler, M. J. ; Mohamed, S. ; Mousa, S. ; Dandona, P. / Estrogen receptor-α in the inhibition of cancer growth and angiogenesis. In: Cancer Research. 2000 ; Vol. 60, No. 24. pp. 7094-7098.
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