Eu, gd-codoped yttria nanoprobes for optical and t1 -weighted magnetic resonance imaging

Timur Sh Atabaev, Jong Ho Lee, Yong Cheol Shin, Dong Wook Han, Ki Seok Choo, Ung Bae Jeon, Jae Yeon Hwang, Jeong A. Yeom, Hyung Kook Kim, Yoon Hwae Hwang

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Abstract

Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y2 O3 nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL). The cytotoxicity test showed that the prepared lanthanide-doped Y2 O3 nanoprobes have good biocompatibility. The obvious contrast enhancement in the T1 -weighted MR images suggested that these nanoprobes can be used as a positive contrast agent in MRI. In addition, the clear fluorescence images of the L-929 cells incubated with the nanoprobes highlight their potential for optical imaging. Overall, these results suggest that prepared lanthanide-doped Y2 O3 nanoprobes can be used for simultaneous optical and MR imaging.

Original languageEnglish
Article number35
JournalNanomaterials
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 10 2017
Externally publishedYes

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Keywords

  • Cytotoxicity
  • Magnetic resonance imaging
  • Nanoprobes
  • Optical imaging
  • T1 -weighted contrast agent
  • Yttria

ASJC Scopus subject areas

  • Materials Science(all)
  • Chemical Engineering(all)

Cite this

Atabaev, T. S., Lee, J. H., Shin, Y. C., Han, D. W., Choo, K. S., Jeon, U. B., Hwang, J. Y., Yeom, J. A., Kim, H. K., & Hwang, Y. H. (2017). Eu, gd-codoped yttria nanoprobes for optical and t1 -weighted magnetic resonance imaging. Nanomaterials, 7(2), [35]. https://doi.org/10.3390/nano7020035