Evaluation of clinical characteristics linked with the survival of patients with advanced-stage ovarian malignancies

Miroslav Popovic, Milan Terzic, Jelena Dotlic, Arnela Ceric-Banicevic

Research output: Contribution to journalReview article

Abstract

Purpose: To evaluate the potential influence of clinical characteristics on survival of patients with advanced-stage of ovarian malignancies. Methods: The study included 163 women with FIGO stages 3 and 4 ovarian malignancies. Detailed history (family history of malignancies, age, menopausal status, body mass index (BMI), parity, comorbidities, symptoms/signs) was taken from all patients including tumor histopathological findings. Patients were postoperatively followed up to 5 years and adverse events were recorded. Univariate and multivariate survival analyses were applied. Results: Patient median survival was 22.77 months (range 1-91). Almost 74% of women survived in the first postoperative year, but only 12.9% had 5-year survival. In the postoperative period, each additional 6 months presented significant risk for unfavorable outcome. Women who were menopausal (p=0.033) and especially if older than 65 years (p=0.016) had worse prognosis. Patients with BMI ?25 kg/ m2 had significantly longer postoperative survival (p=0.005; obesity hazard ratio/HR=1.525). Women with other gynecological or chronic illnesses had a significantly shorter postoperative survival (p=0.038; hazard ratio/HR=1.450). There were no significant differences in postoperative survival regarding patients’ parity, presence of symptoms or positive family history. Two significant models adjusted for FIGO stage (p=0.046) and histological tumor type (p=0.003) encompassing all assessed patient characteristics that could influence survival were obtained. Conclusions: The most important clinical characteristics that can be predictors of survival of patients with advanced ovarian malignancies are comorbidities and being overweight.

Original languageEnglish
Pages (from-to)966-972
Number of pages7
JournalJournal of B.U.ON.
Volume22
Issue number4
Publication statusPublished - Jul 1 2017

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Survival
Neoplasms
Parity
Comorbidity
Body Mass Index
Survival Analysis
Postoperative Period
Signs and Symptoms
Chronic Disease
Multivariate Analysis
Obesity
History

Keywords

  • Advanced stage ovarian carcinoma
  • Age
  • BMI
  • Comorbidities
  • History
  • Survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Evaluation of clinical characteristics linked with the survival of patients with advanced-stage ovarian malignancies. / Popovic, Miroslav; Terzic, Milan; Dotlic, Jelena; Ceric-Banicevic, Arnela.

In: Journal of B.U.ON., Vol. 22, No. 4, 01.07.2017, p. 966-972.

Research output: Contribution to journalReview article

Popovic, Miroslav ; Terzic, Milan ; Dotlic, Jelena ; Ceric-Banicevic, Arnela. / Evaluation of clinical characteristics linked with the survival of patients with advanced-stage ovarian malignancies. In: Journal of B.U.ON. 2017 ; Vol. 22, No. 4. pp. 966-972.
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