Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer

Masao Noda, Takanori Hattori, Tsuguhiro Kimura, Hiroyuki Naitoh, Tadashi Kodama, Kei Kashima, Massimo Pignatelli

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridization to elucidate its role in cancer progression. Anti-sense RNA probes were synthesized by transcribing the subcloned vector with T7 RNA polymerase in the presence of digoxigenin- labeled UTP. FGF-2 mRNA was located mainly in the cytoplasm around the nuclei of endothelial cells, fibroblasts and carcinoma cells. The expression was more frequently in the diffuse type carcinomas (4/7, 57%) than in the intestinal type tumours (5/23, 22%). The survival rates of advanced gastric cancers with FGF-2 mRNA expression were significantly lower than those without FGF-2 mRNA expression (p <0.01). No significant correlation was seen with other clinicopathological factors. These results suggest that FGF-2 may play an important role for the growth of diffuse type gastric cancers, particularly at their advanced stage.

Original languageEnglish
Pages (from-to)695-700
Number of pages6
JournalActa Oncologica
Volume36
Issue number7
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Fibroblast Growth Factor 2
Stomach Neoplasms
Messenger RNA
RNA Probes
Carcinoma
Digoxigenin
Antisense RNA
Uridine Triphosphate
In Situ Hybridization
Neoplasms
Cytoplasm
Endothelial Cells
Fibroblasts
Growth

ASJC Scopus subject areas

  • Oncology

Cite this

Noda, M., Hattori, T., Kimura, T., Naitoh, H., Kodama, T., Kashima, K., & Pignatelli, M. (1997). Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer. Acta Oncologica, 36(7), 695-700.

Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer. / Noda, Masao; Hattori, Takanori; Kimura, Tsuguhiro; Naitoh, Hiroyuki; Kodama, Tadashi; Kashima, Kei; Pignatelli, Massimo.

In: Acta Oncologica, Vol. 36, No. 7, 1997, p. 695-700.

Research output: Contribution to journalArticle

Noda, M, Hattori, T, Kimura, T, Naitoh, H, Kodama, T, Kashima, K & Pignatelli, M 1997, 'Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer', Acta Oncologica, vol. 36, no. 7, pp. 695-700.
Noda M, Hattori T, Kimura T, Naitoh H, Kodama T, Kashima K et al. Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer. Acta Oncologica. 1997;36(7):695-700.
Noda, Masao ; Hattori, Takanori ; Kimura, Tsuguhiro ; Naitoh, Hiroyuki ; Kodama, Tadashi ; Kashima, Kei ; Pignatelli, Massimo. / Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer. In: Acta Oncologica. 1997 ; Vol. 36, No. 7. pp. 695-700.
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