Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer

Masao Noda; Takanori Hattori; Tsuguhiro Kimura; Hiroyuki Naitoh; Tadashi Kodama; Kei Kashima; Massimo Pignatelli

doi:10.3109/02841869709001339

Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer

Masao Noda, Takanori Hattori, Tsuguhiro Kimura, Hiroyuki Naitoh, Tadashi Kodama, Kei Kashima, Massimo Pignatelli

School of Medicine

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridization to elucidate its role in cancer progression. Anti-sense RNA probes were synthesized by transcribing the subcloned vector with T7 RNA polymerase in the presence of digoxigenin- labeled UTP. FGF-2 mRNA was located mainly in the cytoplasm around the nuclei of endothelial cells, fibroblasts and carcinoma cells. The expression was more frequently in the diffuse type carcinomas (4/7, 57%) than in the intestinal type tumours (5/23, 22%). The survival rates of advanced gastric cancers with FGF-2 mRNA expression were significantly lower than those without FGF-2 mRNA expression (p < 0.01). No significant correlation was seen with other clinicopathological factors. These results suggest that FGF-2 may play an important role for the growth of diffuse type gastric cancers, particularly at their advanced stage.

Original language	English
Pages (from-to)	695-700
Number of pages	6
Journal	Acta Oncologica
Volume	36
Issue number	7
DOIs	https://doi.org/10.3109/02841869709001339
Publication status	Published - Jan 1 1997

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

Access to Document

10.3109/02841869709001339

Fingerprint Dive into the research topics of 'Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer'. Together they form a unique fingerprint.

Cite this

Noda, M., Hattori, T., Kimura, T., Naitoh, H., Kodama, T., Kashima, K., & Pignatelli, M. (1997). Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer. Acta Oncologica, 36(7), 695-700. https://doi.org/10.3109/02841869709001339

@article{eac81b3c09954fe0a15d2043df24a7ff,

title = "Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer",

abstract = "We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridization to elucidate its role in cancer progression. Anti-sense RNA probes were synthesized by transcribing the subcloned vector with T7 RNA polymerase in the presence of digoxigenin- labeled UTP. FGF-2 mRNA was located mainly in the cytoplasm around the nuclei of endothelial cells, fibroblasts and carcinoma cells. The expression was more frequently in the diffuse type carcinomas (4/7, 57%) than in the intestinal type tumours (5/23, 22%). The survival rates of advanced gastric cancers with FGF-2 mRNA expression were significantly lower than those without FGF-2 mRNA expression (p < 0.01). No significant correlation was seen with other clinicopathological factors. These results suggest that FGF-2 may play an important role for the growth of diffuse type gastric cancers, particularly at their advanced stage.",

author = "Masao Noda and Takanori Hattori and Tsuguhiro Kimura and Hiroyuki Naitoh and Tadashi Kodama and Kei Kashima and Massimo Pignatelli",

year = "1997",

month = jan,

day = "1",

doi = "10.3109/02841869709001339",

language = "English",

volume = "36",

pages = "695--700",

journal = "Acta Oncologica",

issn = "0284-186X",

publisher = "Informa Healthcare",

number = "7",

}

TY - JOUR

T1 - Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer

AU - Noda, Masao

AU - Hattori, Takanori

AU - Kimura, Tsuguhiro

AU - Naitoh, Hiroyuki

AU - Kodama, Tadashi

AU - Kashima, Kei

AU - Pignatelli, Massimo

PY - 1997/1/1

Y1 - 1997/1/1

N2 - We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridization to elucidate its role in cancer progression. Anti-sense RNA probes were synthesized by transcribing the subcloned vector with T7 RNA polymerase in the presence of digoxigenin- labeled UTP. FGF-2 mRNA was located mainly in the cytoplasm around the nuclei of endothelial cells, fibroblasts and carcinoma cells. The expression was more frequently in the diffuse type carcinomas (4/7, 57%) than in the intestinal type tumours (5/23, 22%). The survival rates of advanced gastric cancers with FGF-2 mRNA expression were significantly lower than those without FGF-2 mRNA expression (p < 0.01). No significant correlation was seen with other clinicopathological factors. These results suggest that FGF-2 may play an important role for the growth of diffuse type gastric cancers, particularly at their advanced stage.

AB - We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridization to elucidate its role in cancer progression. Anti-sense RNA probes were synthesized by transcribing the subcloned vector with T7 RNA polymerase in the presence of digoxigenin- labeled UTP. FGF-2 mRNA was located mainly in the cytoplasm around the nuclei of endothelial cells, fibroblasts and carcinoma cells. The expression was more frequently in the diffuse type carcinomas (4/7, 57%) than in the intestinal type tumours (5/23, 22%). The survival rates of advanced gastric cancers with FGF-2 mRNA expression were significantly lower than those without FGF-2 mRNA expression (p < 0.01). No significant correlation was seen with other clinicopathological factors. These results suggest that FGF-2 may play an important role for the growth of diffuse type gastric cancers, particularly at their advanced stage.

UR - http://www.scopus.com/inward/record.url?scp=0031415992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031415992&partnerID=8YFLogxK

U2 - 10.3109/02841869709001339

DO - 10.3109/02841869709001339

M3 - Article

C2 - 9490085

AN - SCOPUS:0031415992

VL - 36

SP - 695

EP - 700

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 7

ER -