Expression of fibroblast growth factor 2 mRNA in early and advanced gastric cancer

Masao Noda, Takanori Hattori, Tsuguhiro Kimura, Hiroyuki Naitoh, Tadashi Kodama, Kei Kashima, Massimo Pignatelli

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11 Citations (Scopus)


We examined the expression of FGF-2 mRNA in 16 early and 14 advanced gastric cancer by in situ hybridization to elucidate its role in cancer progression. Anti-sense RNA probes were synthesized by transcribing the subcloned vector with T7 RNA polymerase in the presence of digoxigenin- labeled UTP. FGF-2 mRNA was located mainly in the cytoplasm around the nuclei of endothelial cells, fibroblasts and carcinoma cells. The expression was more frequently in the diffuse type carcinomas (4/7, 57%) than in the intestinal type tumours (5/23, 22%). The survival rates of advanced gastric cancers with FGF-2 mRNA expression were significantly lower than those without FGF-2 mRNA expression (p < 0.01). No significant correlation was seen with other clinicopathological factors. These results suggest that FGF-2 may play an important role for the growth of diffuse type gastric cancers, particularly at their advanced stage.

Original languageEnglish
Pages (from-to)695-700
Number of pages6
JournalActa Oncologica
Issue number7
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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