Expression of the met-receptor and its ligand, HGF-SF during mouse embryogenesis.

E. Sonnenberg, K. M. Weidner, C. Birchmeier

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

We have determined the expression patterns of the met proto-oncogene and the gene which encodes its ligand, scatter factor/hepatocyte growth factor (HGF-SF), during mouse embryogenesis. A recurring pattern of expression was found in a variety of different organs: expression of met in specific epithelial cells, and transcripts for the HGF-SF gene in mesenchymal cells in close vicinity. Exchange of signals between mesenchymal and epithelial cell compartments are important in morphogenesis and differentiation of a variety of embryonal organs, although their molecular basis has not been elucidated. The observed expression of met and HGF-SF during development suggests that this receptor and its specific ligand might play a role in such processes. In addition to this distinct pattern, expression of met in certain epithelia and HGF-SF in the surrounding mesenchyme, we find met transcripts in neural, endothelial and muscle cells and transcripts for HGF-SF in neural and muscle tissue. In no instance did we observe both, transcripts for the receptor and the ligand, in the same cells. This suggests a paracrine mode of action for HGF-SF and its receptor during development. This exchange of signals might thus regulate a variety of processes, notably among them mesenchymal epithelial interactions.

Original languageEnglish
Pages (from-to)381-394
Number of pages14
JournalEXS
Volume65
Publication statusPublished - 1993
Externally publishedYes

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Embryonic Development
Hepatocyte Growth Factor
Ligands
Epithelial Cells
Proto-Oncogenes
Mesoderm
Morphogenesis
Muscle Cells
Genes
Epithelium
Endothelial Cells
Muscles

ASJC Scopus subject areas

  • Medicine(all)

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Expression of the met-receptor and its ligand, HGF-SF during mouse embryogenesis. / Sonnenberg, E.; Weidner, K. M.; Birchmeier, C.

In: EXS, Vol. 65, 1993, p. 381-394.

Research output: Contribution to journalReview article

Sonnenberg, E. ; Weidner, K. M. ; Birchmeier, C. / Expression of the met-receptor and its ligand, HGF-SF during mouse embryogenesis. In: EXS. 1993 ; Vol. 65. pp. 381-394.
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