Expression patterns of β-catenin in in situ and invasive breast cancer

A. J. Karayiannakis, L. Nakopoulou, H. Gakiopoulou, A. Keramopoulos, P. S. Davaris, M. Pignatelli

Research output: Contribution to journalArticle

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Abstract

Background. β-Catenin plays a central role in the E-cadherin/catenin cell-cell adhesion complex and is possibly involved in cellular signalling pathways. In this study, we evaluated the expression patterns of this molecule in in situ and invasive breast cancer. Methods. The expression of β-catenin was evaluated in 121 breast cancer specimens by immunohistochemistry. Its relationship to clinicopathological features was also investigated. Results. Altered β-catenin expression was found in 68% of tumours. Lobular carcinomas showed abnormal β-catenin expression more frequently (77%) than ductal carcinomas (64%) with 46% of lobular cases showing complete absence of β-catenin immunoreactivity. Cytoplasmic β-catenin localization was seen only in ductal carcinomas. Aberrant β-catenin expression was observed in 54% of ductal carcinomas in situ with highly concordant β-catenin expression patterns in the nearby in situ and invasive components. Conclusions. Quantitative and qualitative changes in β-catenin expression occur in a considerable proportion of in situ and invasive ductal carcinomas and are more prominent in invasive lobular carcinomas.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume27
Issue number1
DOIs
Publication statusPublished - 2001
Externally publishedYes

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Catenins
Breast Neoplasms
Lobular Carcinoma
Ductal Carcinoma
Carcinoma, Intraductal, Noninfiltrating
Cadherins
Cell Adhesion
Immunohistochemistry

Keywords

  • β-catenin
  • Breast cancer
  • Cell adhesion
  • Ductal carcinoma in situ
  • Immunohistochemistry

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Karayiannakis, A. J., Nakopoulou, L., Gakiopoulou, H., Keramopoulos, A., Davaris, P. S., & Pignatelli, M. (2001). Expression patterns of β-catenin in in situ and invasive breast cancer. European Journal of Surgical Oncology, 27(1), 31-36. https://doi.org/10.1053/ejso.1999.1017

Expression patterns of β-catenin in in situ and invasive breast cancer. / Karayiannakis, A. J.; Nakopoulou, L.; Gakiopoulou, H.; Keramopoulos, A.; Davaris, P. S.; Pignatelli, M.

In: European Journal of Surgical Oncology, Vol. 27, No. 1, 2001, p. 31-36.

Research output: Contribution to journalArticle

Karayiannakis, AJ, Nakopoulou, L, Gakiopoulou, H, Keramopoulos, A, Davaris, PS & Pignatelli, M 2001, 'Expression patterns of β-catenin in in situ and invasive breast cancer', European Journal of Surgical Oncology, vol. 27, no. 1, pp. 31-36. https://doi.org/10.1053/ejso.1999.1017
Karayiannakis, A. J. ; Nakopoulou, L. ; Gakiopoulou, H. ; Keramopoulos, A. ; Davaris, P. S. ; Pignatelli, M. / Expression patterns of β-catenin in in situ and invasive breast cancer. In: European Journal of Surgical Oncology. 2001 ; Vol. 27, No. 1. pp. 31-36.
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AU - Davaris, P. S.

AU - Pignatelli, M.

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AB - Background. β-Catenin plays a central role in the E-cadherin/catenin cell-cell adhesion complex and is possibly involved in cellular signalling pathways. In this study, we evaluated the expression patterns of this molecule in in situ and invasive breast cancer. Methods. The expression of β-catenin was evaluated in 121 breast cancer specimens by immunohistochemistry. Its relationship to clinicopathological features was also investigated. Results. Altered β-catenin expression was found in 68% of tumours. Lobular carcinomas showed abnormal β-catenin expression more frequently (77%) than ductal carcinomas (64%) with 46% of lobular cases showing complete absence of β-catenin immunoreactivity. Cytoplasmic β-catenin localization was seen only in ductal carcinomas. Aberrant β-catenin expression was observed in 54% of ductal carcinomas in situ with highly concordant β-catenin expression patterns in the nearby in situ and invasive components. Conclusions. Quantitative and qualitative changes in β-catenin expression occur in a considerable proportion of in situ and invasive ductal carcinomas and are more prominent in invasive lobular carcinomas.

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