Expression patterns of the novel catenin p120cas in gastrointestinal cancers

Anastasios J. Karayiannakis, Konstantinos N. Syrigos, Demetrios Alexiou, Nicolaos Kalahanis, Theophilos Rosenberg, Elias Bastounis, Massimo Pignatelli

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

p120cas is involved in signal transduction upon src or growth factor stimulation as well as in E-cadherin mediated cell adhesion and may play an important role in carcinogenesis. In this study, we evaluated immunohistochemically the expression and cellular localization of p120cas in 40 gastric, 43 colorectal and 20 pancreatic carcinomas, and examined the relationship between p120cas expression and pathological features. Altered p120cas expression was observed in 70%, 65% and 60% of gastric, colorectal and pancreatic cancers, respectively. The most common abnormality was of cytoplasmic expression associated with loss of membranous distribution found in 37% of gastric, in 25% of colorectal and in 25% of pancreatic cancers. Heterogeneous staining was noted in 15%, 19% and 20%, and complete loss of expression in 18%, 21% and 15% of gastric, colorectal and pancreatic cancers, respectively. There was no correlation between p120cas staining pattern and tumour grade or stage. Aberrant expression of p120cas which may reflect changes in signal transduction pathways occurs frequently in human malignancies.

Original languageEnglish
Pages (from-to)4401-4405
Number of pages5
JournalAnticancer Research
Volume19
Issue number5 C
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Catenins
Gastrointestinal Neoplasms
Pancreatic Neoplasms
Stomach Neoplasms
Colorectal Neoplasms
Signal Transduction
Stomach
Staining and Labeling
Cadherins
Cell Adhesion
delta catenin
Neoplasms
Intercellular Signaling Peptides and Proteins
Carcinogenesis

Keywords

  • Catenins
  • Cell adhesion
  • Colorectal cancer
  • Gastric cancer
  • p120cas
  • Pancreatic cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Karayiannakis, A. J., Syrigos, K. N., Alexiou, D., Kalahanis, N., Rosenberg, T., Bastounis, E., & Pignatelli, M. (1999). Expression patterns of the novel catenin p120cas in gastrointestinal cancers. Anticancer Research, 19(5 C), 4401-4405.

Expression patterns of the novel catenin p120cas in gastrointestinal cancers. / Karayiannakis, Anastasios J.; Syrigos, Konstantinos N.; Alexiou, Demetrios; Kalahanis, Nicolaos; Rosenberg, Theophilos; Bastounis, Elias; Pignatelli, Massimo.

In: Anticancer Research, Vol. 19, No. 5 C, 1999, p. 4401-4405.

Research output: Contribution to journalArticle

Karayiannakis, AJ, Syrigos, KN, Alexiou, D, Kalahanis, N, Rosenberg, T, Bastounis, E & Pignatelli, M 1999, 'Expression patterns of the novel catenin p120cas in gastrointestinal cancers', Anticancer Research, vol. 19, no. 5 C, pp. 4401-4405.
Karayiannakis AJ, Syrigos KN, Alexiou D, Kalahanis N, Rosenberg T, Bastounis E et al. Expression patterns of the novel catenin p120cas in gastrointestinal cancers. Anticancer Research. 1999;19(5 C):4401-4405.
Karayiannakis, Anastasios J. ; Syrigos, Konstantinos N. ; Alexiou, Demetrios ; Kalahanis, Nicolaos ; Rosenberg, Theophilos ; Bastounis, Elias ; Pignatelli, Massimo. / Expression patterns of the novel catenin p120cas in gastrointestinal cancers. In: Anticancer Research. 1999 ; Vol. 19, No. 5 C. pp. 4401-4405.
@article{312d19655d914f4091600cfafc46b5e0,
title = "Expression patterns of the novel catenin p120cas in gastrointestinal cancers",
abstract = "p120cas is involved in signal transduction upon src or growth factor stimulation as well as in E-cadherin mediated cell adhesion and may play an important role in carcinogenesis. In this study, we evaluated immunohistochemically the expression and cellular localization of p120cas in 40 gastric, 43 colorectal and 20 pancreatic carcinomas, and examined the relationship between p120cas expression and pathological features. Altered p120cas expression was observed in 70{\%}, 65{\%} and 60{\%} of gastric, colorectal and pancreatic cancers, respectively. The most common abnormality was of cytoplasmic expression associated with loss of membranous distribution found in 37{\%} of gastric, in 25{\%} of colorectal and in 25{\%} of pancreatic cancers. Heterogeneous staining was noted in 15{\%}, 19{\%} and 20{\%}, and complete loss of expression in 18{\%}, 21{\%} and 15{\%} of gastric, colorectal and pancreatic cancers, respectively. There was no correlation between p120cas staining pattern and tumour grade or stage. Aberrant expression of p120cas which may reflect changes in signal transduction pathways occurs frequently in human malignancies.",
keywords = "Catenins, Cell adhesion, Colorectal cancer, Gastric cancer, p120cas, Pancreatic cancer",
author = "Karayiannakis, {Anastasios J.} and Syrigos, {Konstantinos N.} and Demetrios Alexiou and Nicolaos Kalahanis and Theophilos Rosenberg and Elias Bastounis and Massimo Pignatelli",
year = "1999",
language = "English",
volume = "19",
pages = "4401--4405",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5 C",

}

TY - JOUR

T1 - Expression patterns of the novel catenin p120cas in gastrointestinal cancers

AU - Karayiannakis, Anastasios J.

AU - Syrigos, Konstantinos N.

AU - Alexiou, Demetrios

AU - Kalahanis, Nicolaos

AU - Rosenberg, Theophilos

AU - Bastounis, Elias

AU - Pignatelli, Massimo

PY - 1999

Y1 - 1999

N2 - p120cas is involved in signal transduction upon src or growth factor stimulation as well as in E-cadherin mediated cell adhesion and may play an important role in carcinogenesis. In this study, we evaluated immunohistochemically the expression and cellular localization of p120cas in 40 gastric, 43 colorectal and 20 pancreatic carcinomas, and examined the relationship between p120cas expression and pathological features. Altered p120cas expression was observed in 70%, 65% and 60% of gastric, colorectal and pancreatic cancers, respectively. The most common abnormality was of cytoplasmic expression associated with loss of membranous distribution found in 37% of gastric, in 25% of colorectal and in 25% of pancreatic cancers. Heterogeneous staining was noted in 15%, 19% and 20%, and complete loss of expression in 18%, 21% and 15% of gastric, colorectal and pancreatic cancers, respectively. There was no correlation between p120cas staining pattern and tumour grade or stage. Aberrant expression of p120cas which may reflect changes in signal transduction pathways occurs frequently in human malignancies.

AB - p120cas is involved in signal transduction upon src or growth factor stimulation as well as in E-cadherin mediated cell adhesion and may play an important role in carcinogenesis. In this study, we evaluated immunohistochemically the expression and cellular localization of p120cas in 40 gastric, 43 colorectal and 20 pancreatic carcinomas, and examined the relationship between p120cas expression and pathological features. Altered p120cas expression was observed in 70%, 65% and 60% of gastric, colorectal and pancreatic cancers, respectively. The most common abnormality was of cytoplasmic expression associated with loss of membranous distribution found in 37% of gastric, in 25% of colorectal and in 25% of pancreatic cancers. Heterogeneous staining was noted in 15%, 19% and 20%, and complete loss of expression in 18%, 21% and 15% of gastric, colorectal and pancreatic cancers, respectively. There was no correlation between p120cas staining pattern and tumour grade or stage. Aberrant expression of p120cas which may reflect changes in signal transduction pathways occurs frequently in human malignancies.

KW - Catenins

KW - Cell adhesion

KW - Colorectal cancer

KW - Gastric cancer

KW - p120cas

KW - Pancreatic cancer

UR - http://www.scopus.com/inward/record.url?scp=0033428382&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033428382&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 4401

EP - 4405

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 5 C

ER -