Abstract
p120cas is involved in signal transduction upon src or growth factor stimulation as well as in E-cadherin mediated cell adhesion and may play an important role in carcinogenesis. In this study, we evaluated immunohistochemically the expression and cellular localization of p120cas in 40 gastric, 43 colorectal and 20 pancreatic carcinomas, and examined the relationship between p120cas expression and pathological features. Altered p120cas expression was observed in 70%, 65% and 60% of gastric, colorectal and pancreatic cancers, respectively. The most common abnormality was of cytoplasmic expression associated with loss of membranous distribution found in 37% of gastric, in 25% of colorectal and in 25% of pancreatic cancers. Heterogeneous staining was noted in 15%, 19% and 20%, and complete loss of expression in 18%, 21% and 15% of gastric, colorectal and pancreatic cancers, respectively. There was no correlation between p120cas staining pattern and tumour grade or stage. Aberrant expression of p120cas which may reflect changes in signal transduction pathways occurs frequently in human malignancies.
| Original language | English |
|---|---|
| Pages (from-to) | 4401-4405 |
| Number of pages | 5 |
| Journal | Anticancer Research |
| Volume | 19 |
| Issue number | 5 C |
| Publication status | Published - 1999 |
| Externally published | Yes |
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Keywords
- Catenins
- Cell adhesion
- Colorectal cancer
- Gastric cancer
- p120cas
- Pancreatic cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Expression patterns of the novel catenin p120cas in gastrointestinal cancers. / Karayiannakis, Anastasios J.; Syrigos, Konstantinos N.; Alexiou, Demetrios; Kalahanis, Nicolaos; Rosenberg, Theophilos; Bastounis, Elias; Pignatelli, Massimo.
In: Anticancer Research, Vol. 19, No. 5 C, 1999, p. 4401-4405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Expression patterns of the novel catenin p120cas in gastrointestinal cancers
AU - Karayiannakis, Anastasios J.
AU - Syrigos, Konstantinos N.
AU - Alexiou, Demetrios
AU - Kalahanis, Nicolaos
AU - Rosenberg, Theophilos
AU - Bastounis, Elias
AU - Pignatelli, Massimo
PY - 1999
Y1 - 1999
N2 - p120cas is involved in signal transduction upon src or growth factor stimulation as well as in E-cadherin mediated cell adhesion and may play an important role in carcinogenesis. In this study, we evaluated immunohistochemically the expression and cellular localization of p120cas in 40 gastric, 43 colorectal and 20 pancreatic carcinomas, and examined the relationship between p120cas expression and pathological features. Altered p120cas expression was observed in 70%, 65% and 60% of gastric, colorectal and pancreatic cancers, respectively. The most common abnormality was of cytoplasmic expression associated with loss of membranous distribution found in 37% of gastric, in 25% of colorectal and in 25% of pancreatic cancers. Heterogeneous staining was noted in 15%, 19% and 20%, and complete loss of expression in 18%, 21% and 15% of gastric, colorectal and pancreatic cancers, respectively. There was no correlation between p120cas staining pattern and tumour grade or stage. Aberrant expression of p120cas which may reflect changes in signal transduction pathways occurs frequently in human malignancies.
AB - p120cas is involved in signal transduction upon src or growth factor stimulation as well as in E-cadherin mediated cell adhesion and may play an important role in carcinogenesis. In this study, we evaluated immunohistochemically the expression and cellular localization of p120cas in 40 gastric, 43 colorectal and 20 pancreatic carcinomas, and examined the relationship between p120cas expression and pathological features. Altered p120cas expression was observed in 70%, 65% and 60% of gastric, colorectal and pancreatic cancers, respectively. The most common abnormality was of cytoplasmic expression associated with loss of membranous distribution found in 37% of gastric, in 25% of colorectal and in 25% of pancreatic cancers. Heterogeneous staining was noted in 15%, 19% and 20%, and complete loss of expression in 18%, 21% and 15% of gastric, colorectal and pancreatic cancers, respectively. There was no correlation between p120cas staining pattern and tumour grade or stage. Aberrant expression of p120cas which may reflect changes in signal transduction pathways occurs frequently in human malignancies.
KW - Catenins
KW - Cell adhesion
KW - Colorectal cancer
KW - Gastric cancer
KW - p120cas
KW - Pancreatic cancer
UR - http://www.scopus.com/inward/record.url?scp=0033428382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033428382&partnerID=8YFLogxK
M3 - Article
VL - 19
SP - 4401
EP - 4405
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 5 C
ER -