Extension of DNA in a nanochannel as a rod-to-coil transition

Douglas R. Tree, Yanwei Wang, Kevin D. Dorfman

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

DNA confinement in nanochannels is emerging as an important tool for genomics and an excellent platform for testing the theories of confined wormlike polymers. Using cutting-edge, large scale Monte Carlo simulations of asymptotically long wormlike chains, we show that, in analogy to the rod-to-coil transition for free wormlike polymers, there exists a universal, Gauss-de Gennes regime that connects the classic Odijk and de Gennes regimes of channel-confined chains. For DNA in a nanochannel, this Gauss-de Gennes regime spans practically the entire experimentally relevant range of channel sizes, including the nanochannels used in an incipient genome mapping technology.

Original languageEnglish
Article number208103
JournalPhysical Review Letters
Volume110
Issue number20
DOIs
Publication statusPublished - May 13 2013

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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