Extra-pulmonary diseases related to mycoplasma pneumoniae in children

Recent insights into the pathogenesis

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Purpose of review Providing an overview on Mycoplasma pneumoniae-related extra-pulmonary diseases (MpEPDs) in children, who represent the preferred target population by those complications, and discussing the main pathogenic mechanisms implicated or potentially involved. Recent findings Recent evidences supported the fact that M. pneumoniae is more than an extra-cellular pathogen colonizing epithelial cells of the respiratory tract. It is able to penetrate the cell membrane of host cells and to invade the respiratory mucosa, leading to pronounced inflammatory responses and also spreading outside the respiratory system, to some extent. Thus, direct and indirect (immune-mediated) mechanisms have been described in M. pneumoniae infections, but the latter ones have been mainly implicated in MpEPDs, as reviewed here. Recently, interesting insights have been provided, especially as concern neurologic complications, and new potential mechanisms of disease have been emerging for autoimmunity. Summary The awareness of the occurrence of MpEPDs, showing very variable clinical expressions, could promote a correct diagnosis and an appropriate treatment. The knowledge of disease mechanisms in MpEPDs is largely incomplete, but recent advances from clinical studies and murine models might promote and direct future research.

Original languageEnglish
Pages (from-to)380-387
Number of pages8
JournalCurrent Opinion in Rheumatology
Volume30
Issue number4
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Mycoplasma pneumoniae
Lung Diseases
Respiratory System
Respiratory Mucosa
Health Services Needs and Demand
Autoimmunity
Nervous System
Epithelial Cells
Cell Membrane
Infection

Keywords

  • children
  • M. pneumoniae
  • M. pneumoniae -related extra-pulmonary diseases
  • pathogenesis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Extra-pulmonary diseases related to mycoplasma pneumoniae in children : Recent insights into the pathogenesis. / Poddighe, DImitri.

In: Current Opinion in Rheumatology, Vol. 30, No. 4, 01.07.2018, p. 380-387.

Research output: Contribution to journalReview article

@article{06e814dc0959496eae18b0e5a5a1f895,
title = "Extra-pulmonary diseases related to mycoplasma pneumoniae in children: Recent insights into the pathogenesis",
abstract = "Purpose of review Providing an overview on Mycoplasma pneumoniae-related extra-pulmonary diseases (MpEPDs) in children, who represent the preferred target population by those complications, and discussing the main pathogenic mechanisms implicated or potentially involved. Recent findings Recent evidences supported the fact that M. pneumoniae is more than an extra-cellular pathogen colonizing epithelial cells of the respiratory tract. It is able to penetrate the cell membrane of host cells and to invade the respiratory mucosa, leading to pronounced inflammatory responses and also spreading outside the respiratory system, to some extent. Thus, direct and indirect (immune-mediated) mechanisms have been described in M. pneumoniae infections, but the latter ones have been mainly implicated in MpEPDs, as reviewed here. Recently, interesting insights have been provided, especially as concern neurologic complications, and new potential mechanisms of disease have been emerging for autoimmunity. Summary The awareness of the occurrence of MpEPDs, showing very variable clinical expressions, could promote a correct diagnosis and an appropriate treatment. The knowledge of disease mechanisms in MpEPDs is largely incomplete, but recent advances from clinical studies and murine models might promote and direct future research.",
keywords = "children, M. pneumoniae, M. pneumoniae -related extra-pulmonary diseases, pathogenesis",
author = "DImitri Poddighe",
year = "2018",
month = "7",
day = "1",
doi = "10.1097/BOR.0000000000000494",
language = "English",
volume = "30",
pages = "380--387",
journal = "Current Opinion in Rheumatology",
issn = "1040-8711",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Extra-pulmonary diseases related to mycoplasma pneumoniae in children

T2 - Recent insights into the pathogenesis

AU - Poddighe, DImitri

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Purpose of review Providing an overview on Mycoplasma pneumoniae-related extra-pulmonary diseases (MpEPDs) in children, who represent the preferred target population by those complications, and discussing the main pathogenic mechanisms implicated or potentially involved. Recent findings Recent evidences supported the fact that M. pneumoniae is more than an extra-cellular pathogen colonizing epithelial cells of the respiratory tract. It is able to penetrate the cell membrane of host cells and to invade the respiratory mucosa, leading to pronounced inflammatory responses and also spreading outside the respiratory system, to some extent. Thus, direct and indirect (immune-mediated) mechanisms have been described in M. pneumoniae infections, but the latter ones have been mainly implicated in MpEPDs, as reviewed here. Recently, interesting insights have been provided, especially as concern neurologic complications, and new potential mechanisms of disease have been emerging for autoimmunity. Summary The awareness of the occurrence of MpEPDs, showing very variable clinical expressions, could promote a correct diagnosis and an appropriate treatment. The knowledge of disease mechanisms in MpEPDs is largely incomplete, but recent advances from clinical studies and murine models might promote and direct future research.

AB - Purpose of review Providing an overview on Mycoplasma pneumoniae-related extra-pulmonary diseases (MpEPDs) in children, who represent the preferred target population by those complications, and discussing the main pathogenic mechanisms implicated or potentially involved. Recent findings Recent evidences supported the fact that M. pneumoniae is more than an extra-cellular pathogen colonizing epithelial cells of the respiratory tract. It is able to penetrate the cell membrane of host cells and to invade the respiratory mucosa, leading to pronounced inflammatory responses and also spreading outside the respiratory system, to some extent. Thus, direct and indirect (immune-mediated) mechanisms have been described in M. pneumoniae infections, but the latter ones have been mainly implicated in MpEPDs, as reviewed here. Recently, interesting insights have been provided, especially as concern neurologic complications, and new potential mechanisms of disease have been emerging for autoimmunity. Summary The awareness of the occurrence of MpEPDs, showing very variable clinical expressions, could promote a correct diagnosis and an appropriate treatment. The knowledge of disease mechanisms in MpEPDs is largely incomplete, but recent advances from clinical studies and murine models might promote and direct future research.

KW - children

KW - M. pneumoniae

KW - M. pneumoniae -related extra-pulmonary diseases

KW - pathogenesis

UR - http://www.scopus.com/inward/record.url?scp=85048290477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048290477&partnerID=8YFLogxK

U2 - 10.1097/BOR.0000000000000494

DO - 10.1097/BOR.0000000000000494

M3 - Review article

VL - 30

SP - 380

EP - 387

JO - Current Opinion in Rheumatology

JF - Current Opinion in Rheumatology

SN - 1040-8711

IS - 4

ER -