Fabrication of carbon coated gadolinia particles for dual-mode magnetic resonance and fluorescence imaging

Timur Sh Atabaev, Jong Ho Lee, Dong Wook Han, Hyung Kook Kim, Yoon Hwae Hwang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In the present study, we report a fabrication of dual-mode carbon coated gadolinia C@Gd2O3 particles by a facile hydrothermal synthesis method without using any organic solvents. The prepared C@Gd2O3 particles have a core-shell structure and a narrow size distribution in the range of 261±27 nm. The fluorescent properties of the prepared C@Gd2O3 particles were accessed by a room-temperature photoluminescence study, while the longitudinal relaxivity (r1) was examined by using a clinical 1.5 T MRI scanner. A murine fibroblast L-929 cell line was used to examine the cytotoxicity and capability of the prepared C@Gd2O3 particles for the fluorescent labeling. The obtained results show that the prepared C@Gd2O3 particles could be used as a dual-mode contrast agent for magnetic resonance and fluorescence imaging.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalJournal of Advanced Ceramics
Volume4
Issue number2
DOIs
Publication statusPublished - Jun 1 2015
Externally publishedYes

Keywords

  • carbon
  • core-shell structure
  • fluorescence
  • gadolinia particles
  • magnetic resonance imaging (MRI) contrast agent

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites

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