Fabrication of Nontoxic Dye-Embedded Silica Particles for Live Cell Imaging Purposes

Timur Sh Atabaev, Gulnoza Urmanova, Muhammad Ajmal, Nguyen Hoa Hong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Fluorescent imaging agents are desirable components for biological imaging applications. Herein, silica particles with strong fluorescent properties have been prepared by Stöber process for live cell imaging purposes. The morphological and chemical properties of synthesized dye-embedded silica particles were characterized by field emission scanning electron microscopy, energy dispersive X-ray, and X-ray photoelectron spectroscopy. Photoluminescence spectroscopy was used to investigate the room temperature fluorescence excitation and emission spectra of synthesized silica particles. It was found that this kind of fluorescent silica particles exhibits a good biocompatibility and a cellular uptake of the probes verified that they maintain well their optical properties within the intracellular environment.

Original languageEnglish
Pages (from-to)132-136
Number of pages5
JournalBioNanoScience
Volume3
Issue number2
DOIs
Publication statusPublished - Jun 2013
Externally publishedYes

Keywords

  • Cell imaging
  • Cytotoxicity
  • Fluorescence
  • Silica

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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