Facile synthesis of bifunctional silica-coated core-shell Y 2O 3: Eu 3+,Co 2+ composite particles for biomedical applications

Timur Sh Atabaev, Oh Seong Jin, Jong Ho Lee, Dong Wook Han, Hong Ha Thi Vu, Yoon Hwae Hwang, Hyung Kook Kim

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


In the present study, bifunctional silica-coated Y 2O 3:Eu 3+,Co 2+ spherical-shaped submicron composite particles were successfully prepared using a facile urea-assisted homogenous precipitation method. Synthesized Y 2O 3:Eu 3+,Co 2+ phosphor composites showed both ferromagnetic behaviour and strong visible red luminescence emission. The surface of the Y 2O 3:Eu 3+,Co 2+ phosphor composites was modified with a thin silica layer to enhance the luminescent properties and obtain higher biocompatibility of the samples. The composite particles with silica coatings resulted in a small decrease in the viability of L-929 fibroblastic cells at concentrations lower than 25 ppm and allowed cell imaging via internalization and wide distribution into the cells. Overall, these synthesized novel SiO 2@Y 2O 3:Eu 3+,Co 2+ core-shell phosphor composites with both magnetic and luminescent properties have potential biomedical applications, including bioimaging and diagnosis, and can be also potentially used as MRI contrast agents.

Original languageEnglish
Pages (from-to)9495-9501
Number of pages7
JournalRSC Advances
Issue number25
Publication statusPublished - Oct 21 2012
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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