Factors inducing in-stent restenosis

an in-vitro model.

M. Santin, C. Morris, M. Harrison, L. Mikhalovska, A. W. Lloyd, S. Mikhalovsky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In-stent restenosis is caused by the proliferation of the smooth muscle cells (SMCs) following a host response towards the implanted device. However, the precise biochemical and cellular mechanisms are still not completely understood. In this paper, the behaviour of SMCs has been investigated by an in vitro model where the cells were stimulated by platelet derived growth factor (PDGF) on tissue-like substrates as well as on biomaterials such as stainless steel (St) and diamond-like carbon (DLC)-coated St. The results demonstrated that SMCs have a completely different adhesion mode on St and become particularly prone to proliferation and pro-inflammatory cytokine secretion under PDGF stimulus. This would suggest that restenosis may caused by the accidental contact of the SMC with the St substrate under an inflammatory insult.

Original languageEnglish
Pages (from-to)93-94
Number of pages2
JournalThe Medical journal of Malaysia
Volume59 Suppl B
Publication statusPublished - May 2004
Externally publishedYes

Fingerprint

Smooth Muscle Myocytes
Stents
Steel
Platelet-Derived Growth Factor
Diamond
Stainless Steel
Biocompatible Materials
Carbon
Cytokines
Equipment and Supplies
In Vitro Techniques

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Santin, M., Morris, C., Harrison, M., Mikhalovska, L., Lloyd, A. W., & Mikhalovsky, S. (2004). Factors inducing in-stent restenosis: an in-vitro model. The Medical journal of Malaysia, 59 Suppl B, 93-94.

Factors inducing in-stent restenosis : an in-vitro model. / Santin, M.; Morris, C.; Harrison, M.; Mikhalovska, L.; Lloyd, A. W.; Mikhalovsky, S.

In: The Medical journal of Malaysia, Vol. 59 Suppl B, 05.2004, p. 93-94.

Research output: Contribution to journalArticle

Santin, M, Morris, C, Harrison, M, Mikhalovska, L, Lloyd, AW & Mikhalovsky, S 2004, 'Factors inducing in-stent restenosis: an in-vitro model.', The Medical journal of Malaysia, vol. 59 Suppl B, pp. 93-94.
Santin M, Morris C, Harrison M, Mikhalovska L, Lloyd AW, Mikhalovsky S. Factors inducing in-stent restenosis: an in-vitro model. The Medical journal of Malaysia. 2004 May;59 Suppl B:93-94.
Santin, M. ; Morris, C. ; Harrison, M. ; Mikhalovska, L. ; Lloyd, A. W. ; Mikhalovsky, S. / Factors inducing in-stent restenosis : an in-vitro model. In: The Medical journal of Malaysia. 2004 ; Vol. 59 Suppl B. pp. 93-94.
@article{2024610172684891b67f18afc9dfc06d,
title = "Factors inducing in-stent restenosis: an in-vitro model.",
abstract = "In-stent restenosis is caused by the proliferation of the smooth muscle cells (SMCs) following a host response towards the implanted device. However, the precise biochemical and cellular mechanisms are still not completely understood. In this paper, the behaviour of SMCs has been investigated by an in vitro model where the cells were stimulated by platelet derived growth factor (PDGF) on tissue-like substrates as well as on biomaterials such as stainless steel (St) and diamond-like carbon (DLC)-coated St. The results demonstrated that SMCs have a completely different adhesion mode on St and become particularly prone to proliferation and pro-inflammatory cytokine secretion under PDGF stimulus. This would suggest that restenosis may caused by the accidental contact of the SMC with the St substrate under an inflammatory insult.",
author = "M. Santin and C. Morris and M. Harrison and L. Mikhalovska and Lloyd, {A. W.} and S. Mikhalovsky",
year = "2004",
month = "5",
language = "English",
volume = "59 Suppl B",
pages = "93--94",
journal = "Medical Journal of Malaysia",
issn = "0300-5283",
publisher = "Malaysian Medical Association",

}

TY - JOUR

T1 - Factors inducing in-stent restenosis

T2 - an in-vitro model.

AU - Santin, M.

AU - Morris, C.

AU - Harrison, M.

AU - Mikhalovska, L.

AU - Lloyd, A. W.

AU - Mikhalovsky, S.

PY - 2004/5

Y1 - 2004/5

N2 - In-stent restenosis is caused by the proliferation of the smooth muscle cells (SMCs) following a host response towards the implanted device. However, the precise biochemical and cellular mechanisms are still not completely understood. In this paper, the behaviour of SMCs has been investigated by an in vitro model where the cells were stimulated by platelet derived growth factor (PDGF) on tissue-like substrates as well as on biomaterials such as stainless steel (St) and diamond-like carbon (DLC)-coated St. The results demonstrated that SMCs have a completely different adhesion mode on St and become particularly prone to proliferation and pro-inflammatory cytokine secretion under PDGF stimulus. This would suggest that restenosis may caused by the accidental contact of the SMC with the St substrate under an inflammatory insult.

AB - In-stent restenosis is caused by the proliferation of the smooth muscle cells (SMCs) following a host response towards the implanted device. However, the precise biochemical and cellular mechanisms are still not completely understood. In this paper, the behaviour of SMCs has been investigated by an in vitro model where the cells were stimulated by platelet derived growth factor (PDGF) on tissue-like substrates as well as on biomaterials such as stainless steel (St) and diamond-like carbon (DLC)-coated St. The results demonstrated that SMCs have a completely different adhesion mode on St and become particularly prone to proliferation and pro-inflammatory cytokine secretion under PDGF stimulus. This would suggest that restenosis may caused by the accidental contact of the SMC with the St substrate under an inflammatory insult.

UR - http://www.scopus.com/inward/record.url?scp=16544394838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16544394838&partnerID=8YFLogxK

M3 - Article

VL - 59 Suppl B

SP - 93

EP - 94

JO - Medical Journal of Malaysia

JF - Medical Journal of Malaysia

SN - 0300-5283

ER -