Fever as an important resource for infectious diseases research

Juan José González Plaza, Nataša Hulak, Zhaxybay Zhumadilov, Ainur Akilzhanova

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Fever or pyrexia is a process where normal body temperature is raised over homeostasis conditions. Although many effects of fever over the immune system have been known for a long time, it has not been until recent studies when these effects have been evaluated in several infection processes. Results have been promising, as they have reported new ways of regulation, especially in RNA molecules. In light of these new studies, it seems important to start to evaluate the effects of pyrexia in current research efforts in host-pathogen interactions. Viruses and bacteria are responsible for different types of infectious diseases, and while it is of paramount importance to understand the mechanisms of infection, potential effects of fever on this process may have been overlooked. This is especially relevant because during the course of many infectious diseases the organism develops fever. Due to the lack of specific treatments for many of those afflictions, experimental evaluation in fever-like conditions can potentially bring new insights into the infection process and can ultimately help to develop treatments. The aim of this review is to present evidence that the temperature increase during fever affects the way the infection takes place, for both the pathogen and the host.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalIntractable and Rare Diseases Research
Volume5
Issue number2
DOIs
Publication statusPublished - 2016

Keywords

  • Computational tools
  • Fever
  • Immune system
  • Infectious diseases
  • RNA structure

ASJC Scopus subject areas

  • Medicine(all)

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