Fiber-optic semi-distributed Fabry-Perot interferometer for low-limit label-free detection of CCL5 cancer biomarker

Aida Rakhimbekova, Kuanysh Seitkamal, Baizak Kudaibergenov, Faisal Nazir, Tri Pham, Wilfried Blanc, Luca Vangelista, Daniele Tosi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We present an optical fiber label-free biosensor based on a partially stochastic Fabry-Perot interferometer for the detection of CCL5 (CC Chemokine Ligand 5) cancer biomarker. The sensor has a very simple fabrication process, with a splice-and-cleave approach that requires only one splice and a subsequent cleave at the fiber tip. The enhanced backscattering within the Mg-NP fiber paired with the Fresnel reflection at the fiber tip forms a low-finesse interferometric structure; the inner reflections due to Rayleigh scattering provide an additional layers of phase shifts, forming a semi-distributed interferometer (SDI). The average sensitivity of the SDI sensors has been reported to be 92.5 dB/RIU. Sensors were biofunctionalized for the purpose of detecting CCL5 by means of a silanization process. We report the detection of CCL5 in diluted serum with a sensitivity of 2.947 mRIU for each 10-fold concentration increase and a limit of detection of 17.6 aM.

Original languageEnglish
Article number109953
JournalOptics and Laser Technology
Volume168
DOIs
Publication statusPublished - Jan 2024

Keywords

  • Cancer biomarker detection
  • CCL5
  • Enhanced Rayleigh backscattering
  • Fabry-Perot interferometry
  • Optical fiber biosensors
  • Single-mode fibers

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

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