TY - JOUR
T1 - Fiber-optic semi-distributed Fabry-Perot interferometer for low-limit label-free detection of CCL5 cancer biomarker
AU - Rakhimbekova, Aida
AU - Seitkamal, Kuanysh
AU - Kudaibergenov, Baizak
AU - Nazir, Faisal
AU - Pham, Tri
AU - Blanc, Wilfried
AU - Vangelista, Luca
AU - Tosi, Daniele
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2024/1
Y1 - 2024/1
N2 - We present an optical fiber label-free biosensor based on a partially stochastic Fabry-Perot interferometer for the detection of CCL5 (CC Chemokine Ligand 5) cancer biomarker. The sensor has a very simple fabrication process, with a splice-and-cleave approach that requires only one splice and a subsequent cleave at the fiber tip. The enhanced backscattering within the Mg-NP fiber paired with the Fresnel reflection at the fiber tip forms a low-finesse interferometric structure; the inner reflections due to Rayleigh scattering provide an additional layers of phase shifts, forming a semi-distributed interferometer (SDI). The average sensitivity of the SDI sensors has been reported to be 92.5 dB/RIU. Sensors were biofunctionalized for the purpose of detecting CCL5 by means of a silanization process. We report the detection of CCL5 in diluted serum with a sensitivity of 2.947 mRIU for each 10-fold concentration increase and a limit of detection of 17.6 aM.
AB - We present an optical fiber label-free biosensor based on a partially stochastic Fabry-Perot interferometer for the detection of CCL5 (CC Chemokine Ligand 5) cancer biomarker. The sensor has a very simple fabrication process, with a splice-and-cleave approach that requires only one splice and a subsequent cleave at the fiber tip. The enhanced backscattering within the Mg-NP fiber paired with the Fresnel reflection at the fiber tip forms a low-finesse interferometric structure; the inner reflections due to Rayleigh scattering provide an additional layers of phase shifts, forming a semi-distributed interferometer (SDI). The average sensitivity of the SDI sensors has been reported to be 92.5 dB/RIU. Sensors were biofunctionalized for the purpose of detecting CCL5 by means of a silanization process. We report the detection of CCL5 in diluted serum with a sensitivity of 2.947 mRIU for each 10-fold concentration increase and a limit of detection of 17.6 aM.
KW - Cancer biomarker detection
KW - CCL5
KW - Enhanced Rayleigh backscattering
KW - Fabry-Perot interferometry
KW - Optical fiber biosensors
KW - Single-mode fibers
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U2 - 10.1016/j.optlastec.2023.109953
DO - 10.1016/j.optlastec.2023.109953
M3 - Article
AN - SCOPUS:85168009612
SN - 0030-3992
VL - 168
JO - Optics and Laser Technology
JF - Optics and Laser Technology
M1 - 109953
ER -