Fibroblast growth factor 1 and fibroblast growth factor 2 immunoreactivity in gastrointestinal tumours

Iman El-Hariry, Massimo Pignatelli, Nicholas Lemoine

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Acidic and basic fibroblast growth factors (FGF-1 and FGF-2) are mitogenic polypeptides that may play a role in autocrine and paracrine growth control of malignant tumours. We have examined the expression of FGF-1 and FGF-2 in a series of 41 colorectal tumours (24 adenomas, 17 adenocarcinomas) and 50 gastric adenocarcinomas (23 intestinal, 27 diffuse), using immunohistochemistry. Whereas the FGF-1 distribution was cytoplasmic, FGF-2 was restricted to the nuclei of the epithelial cells. FGF-1 immunoreactivity was detected in all samples (100 per cent), whereas FGF-2 immunoreactivity was seen in 17 adenomas (71 per cent), 13 colorectal carcinomas (76 per cent), and 29 gastric carcinomas (58 per cent). Compared with the normal mucosa, FGF-1 was overexpressed in 42 per cent of colorectal adenomas, 76 per cent of colorectal cancers, and 54 per cent of gastric cancers. Conversely, FGF-2 expression was reduced in 16 (66 per cent), 8 (47 per cent), and 40 (80 per cent) adenomas and colorectal and gastric samples, respectively. We found a significant correlation only between reduced FGF-2 and gastric tumour grade. These data indicate that FGF-1 overexpression occurs in a large proportion of human colorectal and gastric cancers. This may play a role in the progression of these tumours. The topographic variation in FGF-2 expression between normal (nuclear) and tumour (cytoplasmic) cells implies a corresponding functional change that may in turn facilitate tumour growth.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalJournal of Pathology
Volume181
Issue number1
DOIs
Publication statusPublished - Jan 1 1997

Keywords

  • FGF-1
  • FGF-2
  • colorectal adenoma
  • colorectal carcinoma
  • gastric carcinoma
  • immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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