Abstract
It is well known that focused ultrasound has a biologic effect on tissue. High intensity focused ultrasound (HIFU) on a small target area raises the temperature of the tissue enough to denaturate proteins and cause irreversible cell damage. The tight focus of the ultrasound energy allows delivery of the intended dose to a very precise location. The resulting coagulation necrosis is relatively painless. The application of this method in the human clinical setting has required pilot studies on an animal model. Although the treatment had a high success rate, there was a significant percentage of complications, mainly attributed to the technical drawbacks of the procedure. Therefore, this method has been modified for use in humans, and the HIFU is now guided, monitored and controlled by magnetic resonance imaging (MRI). In October 2004, Food and Drug Adiministration (FDA) approved MRI guided focused ultrasound treatment of uterine fibroids in humans. Since then, successful treatment of uterine myomas by HIFU has been performed in thousands of women.
| Original language | English |
|---|---|
| Pages (from-to) | 193-195 |
| Number of pages | 3 |
| Journal | Srpski Arhiv Za Celokupno Lekarstvo |
| Volume | 136 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - Jan 1 2008 |
| Externally published | Yes |
Fingerprint
Keywords
- Focused ultrasound
- Treatment
- Uterine myoma
ASJC Scopus subject areas
- Medicine(all)
Cite this
Focused ultrasound for treatment of uterine myoma : From experimental model to clinical practice. / Terzić, Milan.
In: Srpski Arhiv Za Celokupno Lekarstvo, Vol. 136, No. 3-4, 01.01.2008, p. 193-195.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Focused ultrasound for treatment of uterine myoma
T2 - From experimental model to clinical practice
AU - Terzić, Milan
PY - 2008/1/1
Y1 - 2008/1/1
N2 - It is well known that focused ultrasound has a biologic effect on tissue. High intensity focused ultrasound (HIFU) on a small target area raises the temperature of the tissue enough to denaturate proteins and cause irreversible cell damage. The tight focus of the ultrasound energy allows delivery of the intended dose to a very precise location. The resulting coagulation necrosis is relatively painless. The application of this method in the human clinical setting has required pilot studies on an animal model. Although the treatment had a high success rate, there was a significant percentage of complications, mainly attributed to the technical drawbacks of the procedure. Therefore, this method has been modified for use in humans, and the HIFU is now guided, monitored and controlled by magnetic resonance imaging (MRI). In October 2004, Food and Drug Adiministration (FDA) approved MRI guided focused ultrasound treatment of uterine fibroids in humans. Since then, successful treatment of uterine myomas by HIFU has been performed in thousands of women.
AB - It is well known that focused ultrasound has a biologic effect on tissue. High intensity focused ultrasound (HIFU) on a small target area raises the temperature of the tissue enough to denaturate proteins and cause irreversible cell damage. The tight focus of the ultrasound energy allows delivery of the intended dose to a very precise location. The resulting coagulation necrosis is relatively painless. The application of this method in the human clinical setting has required pilot studies on an animal model. Although the treatment had a high success rate, there was a significant percentage of complications, mainly attributed to the technical drawbacks of the procedure. Therefore, this method has been modified for use in humans, and the HIFU is now guided, monitored and controlled by magnetic resonance imaging (MRI). In October 2004, Food and Drug Adiministration (FDA) approved MRI guided focused ultrasound treatment of uterine fibroids in humans. Since then, successful treatment of uterine myomas by HIFU has been performed in thousands of women.
KW - Focused ultrasound
KW - Treatment
KW - Uterine myoma
UR - http://www.scopus.com/inward/record.url?scp=52049086887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52049086887&partnerID=8YFLogxK
U2 - 10.2298/SARH0804193T
DO - 10.2298/SARH0804193T
M3 - Article
VL - 136
SP - 193
EP - 195
JO - Srpski Arhiv Za Celokupno Lekarstvo
JF - Srpski Arhiv Za Celokupno Lekarstvo
SN - 0370-8179
IS - 3-4
ER -