Focused ultrasound for treatment of uterine myoma

From experimental model to clinical practice

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It is well known that focused ultrasound has a biologic effect on tissue. High intensity focused ultrasound (HIFU) on a small target area raises the temperature of the tissue enough to denaturate proteins and cause irreversible cell damage. The tight focus of the ultrasound energy allows delivery of the intended dose to a very precise location. The resulting coagulation necrosis is relatively painless. The application of this method in the human clinical setting has required pilot studies on an animal model. Although the treatment had a high success rate, there was a significant percentage of complications, mainly attributed to the technical drawbacks of the procedure. Therefore, this method has been modified for use in humans, and the HIFU is now guided, monitored and controlled by magnetic resonance imaging (MRI). In October 2004, Food and Drug Adiministration (FDA) approved MRI guided focused ultrasound treatment of uterine fibroids in humans. Since then, successful treatment of uterine myomas by HIFU has been performed in thousands of women.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalSrpski Arhiv Za Celokupno Lekarstvo
Volume136
Issue number3-4
DOIs
Publication statusPublished - Jan 1 2008
Externally publishedYes

Fingerprint

Myoma
Theoretical Models
Magnetic Resonance Imaging
Leiomyoma
Necrosis
Therapeutics
Animal Models
Food
Temperature
Pharmaceutical Preparations
Proteins

Keywords

  • Focused ultrasound
  • Treatment
  • Uterine myoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Focused ultrasound for treatment of uterine myoma : From experimental model to clinical practice. / Terzić, Milan.

In: Srpski Arhiv Za Celokupno Lekarstvo, Vol. 136, No. 3-4, 01.01.2008, p. 193-195.

Research output: Contribution to journalArticle

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