Formation of a sigmoidal release pattern of core particles coated with layers of soluble and permeable particles

Ryusei Ito, Boris Golman, Kunio Shinohara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A novel method was proposed for the sigmoidal release pattern of core material by dry-based coating of core particles with double layers of permeable particles over soluble particles dispersed in an impermeable wax. A mathematical model was constructed to describe the release curves. This model takes into account the variation of porous structure of the soluble-particle layer with release time due to the slow dissolution of soluble particles. As a result, the sigmoidal release curves were obtained experimentally and the model successfully described the release curves. The delay of release rate during the initial stage of release could be flexibly controlled to increase with a lower fraction of permeable particles in the outer layer, leading to slower dissolution of soluble particles due to the higher resistance to diffusion of soluble material in the permeable-particle layer.

Original languageEnglish
Pages (from-to)377-390
Number of pages14
JournalAdvanced Powder Technology
Volume15
Issue number3
DOIs
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Dissolution
Waxes
Mathematical models
Coatings

Keywords

  • Controlled release
  • Mathematical model
  • Permeable particle layer
  • Sigmoidal release curve
  • Soluble particle layer

ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Formation of a sigmoidal release pattern of core particles coated with layers of soluble and permeable particles. / Ito, Ryusei; Golman, Boris; Shinohara, Kunio.

In: Advanced Powder Technology, Vol. 15, No. 3, 2004, p. 377-390.

Research output: Contribution to journalArticle

@article{481b4c5bff19463c9b8f778cd4cfb4d7,
title = "Formation of a sigmoidal release pattern of core particles coated with layers of soluble and permeable particles",
abstract = "A novel method was proposed for the sigmoidal release pattern of core material by dry-based coating of core particles with double layers of permeable particles over soluble particles dispersed in an impermeable wax. A mathematical model was constructed to describe the release curves. This model takes into account the variation of porous structure of the soluble-particle layer with release time due to the slow dissolution of soluble particles. As a result, the sigmoidal release curves were obtained experimentally and the model successfully described the release curves. The delay of release rate during the initial stage of release could be flexibly controlled to increase with a lower fraction of permeable particles in the outer layer, leading to slower dissolution of soluble particles due to the higher resistance to diffusion of soluble material in the permeable-particle layer.",
keywords = "Controlled release, Mathematical model, Permeable particle layer, Sigmoidal release curve, Soluble particle layer",
author = "Ryusei Ito and Boris Golman and Kunio Shinohara",
year = "2004",
doi = "10.1163/156855204774150163",
language = "English",
volume = "15",
pages = "377--390",
journal = "Advanced Powder Technology",
issn = "0921-8831",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Formation of a sigmoidal release pattern of core particles coated with layers of soluble and permeable particles

AU - Ito, Ryusei

AU - Golman, Boris

AU - Shinohara, Kunio

PY - 2004

Y1 - 2004

N2 - A novel method was proposed for the sigmoidal release pattern of core material by dry-based coating of core particles with double layers of permeable particles over soluble particles dispersed in an impermeable wax. A mathematical model was constructed to describe the release curves. This model takes into account the variation of porous structure of the soluble-particle layer with release time due to the slow dissolution of soluble particles. As a result, the sigmoidal release curves were obtained experimentally and the model successfully described the release curves. The delay of release rate during the initial stage of release could be flexibly controlled to increase with a lower fraction of permeable particles in the outer layer, leading to slower dissolution of soluble particles due to the higher resistance to diffusion of soluble material in the permeable-particle layer.

AB - A novel method was proposed for the sigmoidal release pattern of core material by dry-based coating of core particles with double layers of permeable particles over soluble particles dispersed in an impermeable wax. A mathematical model was constructed to describe the release curves. This model takes into account the variation of porous structure of the soluble-particle layer with release time due to the slow dissolution of soluble particles. As a result, the sigmoidal release curves were obtained experimentally and the model successfully described the release curves. The delay of release rate during the initial stage of release could be flexibly controlled to increase with a lower fraction of permeable particles in the outer layer, leading to slower dissolution of soluble particles due to the higher resistance to diffusion of soluble material in the permeable-particle layer.

KW - Controlled release

KW - Mathematical model

KW - Permeable particle layer

KW - Sigmoidal release curve

KW - Soluble particle layer

UR - http://www.scopus.com/inward/record.url?scp=3042545691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042545691&partnerID=8YFLogxK

U2 - 10.1163/156855204774150163

DO - 10.1163/156855204774150163

M3 - Article

AN - SCOPUS:3042545691

VL - 15

SP - 377

EP - 390

JO - Advanced Powder Technology

JF - Advanced Powder Technology

SN - 0921-8831

IS - 3

ER -