Abstract
In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It appeared that the self-assembled peptide both in the cryo- and hydrogel maintained the β-sheet structure commonly attributed to these.
| Original language | English |
|---|---|
| Pages (from-to) | 226-230 |
| Number of pages | 5 |
| Journal | Journal of Colloid and Interface Science |
| Volume | 368 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 15 2012 |
| Externally published | Yes |
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Keywords
- Dipeptides
- Hydrogels
- Macroporous
- Peptides
- Self-assembly
ASJC Scopus subject areas
- Surfaces, Coatings and Films
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Colloid and Surface Chemistry
Cite this
Formation of macroporous self-assembled hydrogels through cryogelation of Fmoc-Phe-Phe. / Berillo, Dmitriy; Mattiasson, Bo; Galaev, Igor Yu; Kirsebom, Harald.
In: Journal of Colloid and Interface Science, Vol. 368, No. 1, 15.02.2012, p. 226-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Formation of macroporous self-assembled hydrogels through cryogelation of Fmoc-Phe-Phe
AU - Berillo, Dmitriy
AU - Mattiasson, Bo
AU - Galaev, Igor Yu
AU - Kirsebom, Harald
PY - 2012/2/15
Y1 - 2012/2/15
N2 - In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It appeared that the self-assembled peptide both in the cryo- and hydrogel maintained the β-sheet structure commonly attributed to these.
AB - In this study, it was found that macroporous hydrogels were formed when self-assembly of fluorenyl-9-methoxycarbonyl (Fmoc)-diphenylalanine (Phe-Phe) peptides was induced using glucono-δ-lactone (GdL) in apparently frozen samples. Formed cryogels exhibited a heterogeneous structure with pore walls of densely packed fibres of assembled dipeptides and pores in the range 10-100μm. Hydrogels formed from the same composition above the freezing point exhibited a homogenous structure without any apparent porosity. The formed gels were characterised using microscopy techniques, CD-spectroscopy and stress sweeps. The cryogels exhibited less mechanical strength than the hydrogels that might be due to the heterogeneous structure of the former. It appeared that the self-assembled peptide both in the cryo- and hydrogel maintained the β-sheet structure commonly attributed to these.
KW - Dipeptides
KW - Hydrogels
KW - Macroporous
KW - Peptides
KW - Self-assembly
UR - http://www.scopus.com/inward/record.url?scp=84855861204&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855861204&partnerID=8YFLogxK
U2 - 10.1016/j.jcis.2011.11.006
DO - 10.1016/j.jcis.2011.11.006
M3 - Article
C2 - 22129632
AN - SCOPUS:84855861204
VL - 368
SP - 226
EP - 230
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
SN - 0021-9797
IS - 1
ER -