Gd2O3 nanoparticles coated with a fluorescent carbon layer for potential T1-weighted magnetic resonance and cells imaging

Anara Molkenova, Yong Cheol Shin, Moon Sung Kang, Tomiris Mulikova, Dong Wook Han, Timur Atabaev

Research output: Contribution to journalArticle

Abstract

There has been a great interest in the development of new functional contrast agents for biomedical applications. In this study, we report the preparation of bifunctional core–shell nanoprobes that can be used as a T1-weighted magnetic resonance imaging (MRI) contrast agent and fluorescent marker for cells imaging. Various analysis techniques were utilized to analyze the physicochemical properties of prepared nanoprobes. Small-animal MRI scanner (1.5 T) was utilized to measure the T1-weighted relaxivity rate (r1 = 5.57 ± 0.33 mM–1 s–1) of prepared nanoprobes. In addition, we showed that prepared nanoprobes can be also used for optical imaging of living cells. A pilot cytotoxicity study on L-929 fibroblastic cells showed that prepared nanoprobes are relatively safe at concentrations ≤8 μg/ml. Thus, prepared samples can be utilized as a promising bifunctional nanoprobe for in-vivo small animal MRI imaging and in-vitro tissues/cells study.
Original languageEnglish
Pages (from-to)813-817
JournalNanoscience and Nanotechnology Letters
Volume11
DOIs
Publication statusPublished - Jun 2019

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Nanoprobes
Magnetic resonance
Nanoparticles
Carbon
Magnetic Resonance Imaging
Imaging techniques
Contrast Media
Optical Imaging
Animals
Cytotoxicity
Cells
Tissue

Keywords

  • BIMODAL NANOPROBES
  • CARBON COATING
  • Fluorescence
  • gadolinium oxide
  • MRI

ASJC Scopus subject areas

  • Materials Science(all)
  • Chemical Engineering(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Chemistry(all)

Cite this

Gd2O3 nanoparticles coated with a fluorescent carbon layer for potential T1-weighted magnetic resonance and cells imaging. / Molkenova, Anara; Shin, Yong Cheol; Kang, Moon Sung; Mulikova, Tomiris; Han, Dong Wook; Atabaev, Timur.

In: Nanoscience and Nanotechnology Letters, Vol. 11, 06.2019, p. 813-817.

Research output: Contribution to journalArticle

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