Abstract
Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.
| Original language | English |
|---|---|
| Pages (from-to) | 504-510 |
| Number of pages | 7 |
| Journal | Journal of B.U.ON. |
| Volume | 18 |
| Issue number | 2 |
| Publication status | Published - Apr 1 2013 |
| Externally published | Yes |
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Keywords
- Antiproliferative effect
- Breast cancer
- Colon cancer
- Dietary supplement GE132+Natural
- Prostate cancer
ASJC Scopus subject areas
- Hematology
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research
Cite this
GE132+Natural : Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. / Okic-Djordjevic, Ivana; Trivanovic, D.; Krstic, J.; Jaukovic, A.; Mojsilovic, S.; Santibanez, J. F.; Terzic, M.; Vesovic, D.; Bugarski, D.
In: Journal of B.U.ON., Vol. 18, No. 2, 01.04.2013, p. 504-510.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - GE132+Natural
T2 - Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells
AU - Okic-Djordjevic, Ivana
AU - Trivanovic, D.
AU - Krstic, J.
AU - Jaukovic, A.
AU - Mojsilovic, S.
AU - Santibanez, J. F.
AU - Terzic, M.
AU - Vesovic, D.
AU - Bugarski, D.
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.
AB - Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.
KW - Antiproliferative effect
KW - Breast cancer
KW - Colon cancer
KW - Dietary supplement GE132+Natural
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84879592748&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879592748&partnerID=8YFLogxK
M3 - Article
VL - 18
SP - 504
EP - 510
JO - Journal of B.U.ON.
JF - Journal of B.U.ON.
SN - 1107-0625
IS - 2
ER -