GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells

Ivana Okic-Djordjevic, D. Trivanovic, J. Krstic, A. Jaukovic, S. Mojsilovic, J. F. Santibanez, M. Terzic, D. Vesovic, D. Bugarski

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.

Original languageEnglish
Pages (from-to)504-510
Number of pages7
JournalJournal of B.U.ON.
Volume18
Issue number2
Publication statusPublished - Apr 1 2013
Externally publishedYes

Fingerprint

Dietetics
Colonic Neoplasms
Prostatic Neoplasms
Mesenchymal Stromal Cells
Breast Neoplasms
Cell Line
Endothelial Cells
Reishi
Dental Pulp
Neoplasms
Adult Stem Cells
Blood Cell Count
Biological Products
Cell Proliferation
Health
Pharmaceutical Preparations

Keywords

  • Antiproliferative effect
  • Breast cancer
  • Colon cancer
  • Dietary supplement GE132+Natural
  • Prostate cancer

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Okic-Djordjevic, I., Trivanovic, D., Krstic, J., Jaukovic, A., Mojsilovic, S., Santibanez, J. F., ... Bugarski, D. (2013). GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. Journal of B.U.ON., 18(2), 504-510.

GE132+Natural : Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. / Okic-Djordjevic, Ivana; Trivanovic, D.; Krstic, J.; Jaukovic, A.; Mojsilovic, S.; Santibanez, J. F.; Terzic, M.; Vesovic, D.; Bugarski, D.

In: Journal of B.U.ON., Vol. 18, No. 2, 01.04.2013, p. 504-510.

Research output: Contribution to journalArticle

Okic-Djordjevic, I, Trivanovic, D, Krstic, J, Jaukovic, A, Mojsilovic, S, Santibanez, JF, Terzic, M, Vesovic, D & Bugarski, D 2013, 'GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells', Journal of B.U.ON., vol. 18, no. 2, pp. 504-510.
Okic-Djordjevic I, Trivanovic D, Krstic J, Jaukovic A, Mojsilovic S, Santibanez JF et al. GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. Journal of B.U.ON. 2013 Apr 1;18(2):504-510.
Okic-Djordjevic, Ivana ; Trivanovic, D. ; Krstic, J. ; Jaukovic, A. ; Mojsilovic, S. ; Santibanez, J. F. ; Terzic, M. ; Vesovic, D. ; Bugarski, D. / GE132+Natural : Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. In: Journal of B.U.ON. 2013 ; Vol. 18, No. 2. pp. 504-510.
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