GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells

Ivana Okic-Djordjevic, D. Trivanovic, J. Krstic, A. Jaukovic, S. Mojsilovic, J. F. Santibanez, M. Terzic, D. Vesovic, D. Bugarski

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Natural products have been investigated for promising new leads in pharmaceutical development. The purpose of this study was to analyze the biological effect of GE132+Natural, a novel supplement consisting of 5 compounds: Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly. Methods: The antiproliferative activity of GE132+Natural was tested on 3 different human cancer cell lines: MCF7 (breast cancer cells), PC3 (prostate cancer cells), and SW480 (colon cancer cells), as well as on EA.hy 926 (normal human endothelial cell line). In addition, the cytotoxicity of GE132+Natural on the proliferation of primary human mesenchymal stem cells isolated from dental pulp (DP-MSC), along with its in vitro impact on different peripheral blood parameters, was determined. Results: The results revealed high antiproliferative activity of GE132+Natural on all tested cancer cell lines (PC3, MCF7 and SW480), as well as on the EA.hy 926 endothelial cell line in a dose-dependent manner. However, applied in a wide range of concentrations GE132+Natural did not affect both the proliferation of primary mesenchymal stem cells and the peripheral blood cells counts. Conclusion: The data obtained demonstrated that GE132+Natural is effective in inhibiting cancer cell proliferation, indicating its potential beneficial health effects. In addition, the results pointed that adult mesenchymal stem cells might be valuable as a test system for evaluating the toxicity and efficacy of new medicines or chemicals.

Original languageEnglish
Pages (from-to)504-510
Number of pages7
JournalJournal of B.U.ON.
Volume18
Issue number2
Publication statusPublished - Apr 1 2013
Externally publishedYes

Keywords

  • Antiproliferative effect
  • Breast cancer
  • Colon cancer
  • Dietary supplement GE132+Natural
  • Prostate cancer

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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  • Cite this

    Okic-Djordjevic, I., Trivanovic, D., Krstic, J., Jaukovic, A., Mojsilovic, S., Santibanez, J. F., Terzic, M., Vesovic, D., & Bugarski, D. (2013). GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells. Journal of B.U.ON., 18(2), 504-510.