Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer

Ainur Akilzhanova, Zhannur Nurkina, Kuvat Momynaliev, Erlan Ramanculov, Zhaxybai Zhumadilov, Tolebay Rakhypbekov, Naomi Hayashida, Masahiro Nakashima, Noboru Takamura

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: To analyze associations between homocysteine level, MTHFR and FTO rs1477196 polymorphisms and folate status in patients with breast cancer (BC) in order to clarify determinants of hyperhomocysteinemia. Patients and Methods: The study included 315 BC cases and 604 controls. Results: The MTHFRC677T genotype was associated with an increased incidence of BC [Odds ratio (OR)=1.71; 95% Confidential interval (CI)=1.21-2.43]. The MTHFR A1298C genotype was associated with a decreased risk of BC [OR=0.68; 95% CI: 0.49-0.95]. The homocysteine level was not associated with either MTHFR C677T or A1298C, nor with FTO rs1477196, but was inversely correlated with folate status in cancer cases (p

Original languageEnglish
Pages (from-to)4049-4060
Number of pages12
JournalAnticancer Research
Volume33
Issue number9
Publication statusPublished - Sep 2013

Fingerprint

Kazakhstan
Homocysteine
Breast Neoplasms
Folic Acid
Odds Ratio
Genotype
Hyperhomocysteinemia
Incidence
Neoplasms

Keywords

  • Breast cancer
  • Folate
  • FTO
  • Homocysteine
  • Kazakhstan
  • MTHFR
  • Polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Akilzhanova, A., Nurkina, Z., Momynaliev, K., Ramanculov, E., Zhumadilov, Z., Rakhypbekov, T., ... Takamura, N. (2013). Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer. Anticancer Research, 33(9), 4049-4060.

Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer. / Akilzhanova, Ainur; Nurkina, Zhannur; Momynaliev, Kuvat; Ramanculov, Erlan; Zhumadilov, Zhaxybai; Rakhypbekov, Tolebay; Hayashida, Naomi; Nakashima, Masahiro; Takamura, Noboru.

In: Anticancer Research, Vol. 33, No. 9, 09.2013, p. 4049-4060.

Research output: Contribution to journalArticle

Akilzhanova, A, Nurkina, Z, Momynaliev, K, Ramanculov, E, Zhumadilov, Z, Rakhypbekov, T, Hayashida, N, Nakashima, M & Takamura, N 2013, 'Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer', Anticancer Research, vol. 33, no. 9, pp. 4049-4060.
Akilzhanova, Ainur ; Nurkina, Zhannur ; Momynaliev, Kuvat ; Ramanculov, Erlan ; Zhumadilov, Zhaxybai ; Rakhypbekov, Tolebay ; Hayashida, Naomi ; Nakashima, Masahiro ; Takamura, Noboru. / Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer. In: Anticancer Research. 2013 ; Vol. 33, No. 9. pp. 4049-4060.
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