Genetics - Cellular basis

Andrea Buda, Massimo Pignatelli

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Colorectal carcinogenesis is a multistep process during which the specialised epithelial cells of intestinal mucosa surface (e.g. colonocytes) accumulate a series of genetic and epigenetic events which lead to a perturbation of their normal cellular functions and turnover. This review will address the mechanisms and biological effects of these abnormalities on the growth control, differentiation, adhesion and survival of the colonocytes.

Original languageEnglish
Pages (from-to)45-58
Number of pages14
JournalBritish Medical Bulletin
Volume64
DOIs
Publication statusPublished - Nov 10 2002

ASJC Scopus subject areas

  • Medicine(all)

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