Abstract
Colorectal carcinogenesis is a multistep process during which the specialised epithelial cells of intestinal mucosa surface (e.g. colonocytes) accumulate a series of genetic and epigenetic events which lead to a perturbation of their normal cellular functions and turnover. This review will address the mechanisms and biological effects of these abnormalities on the growth control, differentiation, adhesion and survival of the colonocytes.
Original language | English |
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Pages (from-to) | 45-58 |
Number of pages | 14 |
Journal | British Medical Bulletin |
Volume | 64 |
DOIs | |
Publication status | Published - 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine