Genome imprinting and development in the mouse

M A Surani, R Kothary, N D Allen, P B Singh, R Fundele, A C Ferguson-Smith, S C Barton

Research output: Contribution to journalReview article

108 Citations (Scopus)

Abstract

Development in mammals is influenced by genome imprinting which results in differences in the expression of some homologous maternal and paternal alleles. This process, initiated in the germline, can continue following fertilization with interactions between oocyte cytoplasmic factors and the parental genomes involving modifier genes. Further epigenetic modifications may follow to render the 'imprints' heritable through subsequent cell divisions during development. Imprinting of genes can be critical for their dosage affecting embryonic growth, cell proliferation and differentiation. The cumulative effects of all the imprinted genes are observed in androgenones (AG) and parthenogenones (PG), which reveal complementary phenotypes with respect to embryonic and extraembryonic tissues. The presence of PG cells in chimeras causes growth retardation, while that of AG cells enhanced growth. AG cells apparently have a higher cell proliferation rate and, unlike PG cells, are less prone to selective elimination. However, the PG germ cells are exempt from cell selection. In chimeras, PG cells are more likely to be found in ectodermal derivatives such as epidermis and brain in contrast to AG cells which make pronounced contributions to many mesodermal derivatives such as muscle, kidney, dermis and skeleton. The presence of androgenetic cells in chimeras also results in the disproportionate elongation of the anterior-posterior axis and sometimes in the abnormal development of skeletal elements along the axis. Genetic studies high-light the influence of subsets of imprinted genes, and identify those that are critical for development.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalDevelopment (Cambridge, England). Supplement
Publication statusPublished - 1990

Fingerprint

Genome
Growth
Cell Proliferation
Modifier Genes
Genes
Dermis
Fertilization
Epigenomics
Skeleton
Epidermis
Germ Cells
Cell Division
Oocytes
Cell Differentiation
Mammals
Alleles
Mothers
Phenotype
Kidney
Light

Keywords

  • Animals
  • Blastocyst
  • Chromosomes
  • Dosage Compensation, Genetic
  • Gene Expression
  • Gene Expression Regulation
  • Mice
  • Mice, Transgenic
  • Journal Article
  • Review

Cite this

Surani, M. A., Kothary, R., Allen, N. D., Singh, P. B., Fundele, R., Ferguson-Smith, A. C., & Barton, S. C. (1990). Genome imprinting and development in the mouse. Development (Cambridge, England). Supplement, 89-98.

Genome imprinting and development in the mouse. / Surani, M A; Kothary, R; Allen, N D; Singh, P B; Fundele, R; Ferguson-Smith, A C; Barton, S C.

In: Development (Cambridge, England). Supplement, 1990, p. 89-98.

Research output: Contribution to journalReview article

Surani, MA, Kothary, R, Allen, ND, Singh, PB, Fundele, R, Ferguson-Smith, AC & Barton, SC 1990, 'Genome imprinting and development in the mouse', Development (Cambridge, England). Supplement, pp. 89-98.
Surani MA, Kothary R, Allen ND, Singh PB, Fundele R, Ferguson-Smith AC et al. Genome imprinting and development in the mouse. Development (Cambridge, England). Supplement. 1990;89-98.
Surani, M A ; Kothary, R ; Allen, N D ; Singh, P B ; Fundele, R ; Ferguson-Smith, A C ; Barton, S C. / Genome imprinting and development in the mouse. In: Development (Cambridge, England). Supplement. 1990 ; pp. 89-98.
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AU - Barton, S C

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AB - Development in mammals is influenced by genome imprinting which results in differences in the expression of some homologous maternal and paternal alleles. This process, initiated in the germline, can continue following fertilization with interactions between oocyte cytoplasmic factors and the parental genomes involving modifier genes. Further epigenetic modifications may follow to render the 'imprints' heritable through subsequent cell divisions during development. Imprinting of genes can be critical for their dosage affecting embryonic growth, cell proliferation and differentiation. The cumulative effects of all the imprinted genes are observed in androgenones (AG) and parthenogenones (PG), which reveal complementary phenotypes with respect to embryonic and extraembryonic tissues. The presence of PG cells in chimeras causes growth retardation, while that of AG cells enhanced growth. AG cells apparently have a higher cell proliferation rate and, unlike PG cells, are less prone to selective elimination. However, the PG germ cells are exempt from cell selection. In chimeras, PG cells are more likely to be found in ectodermal derivatives such as epidermis and brain in contrast to AG cells which make pronounced contributions to many mesodermal derivatives such as muscle, kidney, dermis and skeleton. The presence of androgenetic cells in chimeras also results in the disproportionate elongation of the anterior-posterior axis and sometimes in the abnormal development of skeletal elements along the axis. Genetic studies high-light the influence of subsets of imprinted genes, and identify those that are critical for development.

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