Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles

Experiments and numerical simulations

Goran T. Vladisavljević, Hamed Shahmohamadi, Diganta B. Das, Ekanem E. Ekanem, Zhandos Tauanov, Lav Sharma

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Hypothesis: Droplet size in microfluidic devices is affected by wettability of the microfluidic channels. Three-dimensional countercurrent flow focusing using assemblies of chemically inert glass capillaries is expected to minimize wetting of the channel walls by the organic solvent. Experiments: Monodispersed polycaprolactone and poly(lactic acid) particles with a diameter of 18-150. μm were produced by evaporation of solvent (dichloromethane or 1:2 mixture of chloroform and toluene) from oil-in-water or water-in-oil-in-water emulsions produced in three-dimensional flow focusing glass capillary devices. The drop generation behaviour was simulated numerically using the volume of fluid method. Findings: The numerical results showed good agreement with high-speed video recordings. Monodispersed droplets were produced in the dripping regime when the ratio of the continuous phase flow rate to dispersed phase flow rate was 5-20 and the Weber number of the dispersed phase was less than 0.01. The porosity of polycaprolactone particles increased from 8 to 62% when 30. wt% of the water phase was incorporated in the organic phase prior to emulsification. The inner water phase was loaded with 0.156. wt% lidocaine hydrochloride to achieve a sustained drug release. 26% of lidocaine was released after 1. h and more than 93% of the drug was released after 130. h.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalJournal of Colloid and Interface Science
Volume418
DOIs
Publication statusPublished - Mar 5 2014
Externally publishedYes

Fingerprint

Polycaprolactone
Lactic acid
Microfluidics
Lactic Acid
Glass
Water
Computer simulation
Lidocaine
Experiments
Wetting
Oils
Flow rate
Video recording
Emulsification
Methylene Chloride
Dichloromethane
Toluene
Chloroform
Chlorine compounds
Emulsions

Keywords

  • Computational fluid dynamics
  • Controlled drug release
  • Drop microfluidics
  • Flow focusing
  • Lidocaine hydrochloride
  • Monodispersed microparticle
  • Poly(lactic acid)
  • Polycaprolactone
  • Porous particle
  • Ultrasound contrast agent

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Colloid and Surface Chemistry

Cite this

Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles : Experiments and numerical simulations. / Vladisavljević, Goran T.; Shahmohamadi, Hamed; Das, Diganta B.; Ekanem, Ekanem E.; Tauanov, Zhandos; Sharma, Lav.

In: Journal of Colloid and Interface Science, Vol. 418, 05.03.2014, p. 163-170.

Research output: Contribution to journalArticle

Vladisavljević, Goran T. ; Shahmohamadi, Hamed ; Das, Diganta B. ; Ekanem, Ekanem E. ; Tauanov, Zhandos ; Sharma, Lav. / Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles : Experiments and numerical simulations. In: Journal of Colloid and Interface Science. 2014 ; Vol. 418. pp. 163-170.
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