Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles: Experiments and numerical simulations

Goran T. Vladisavljević, Hamed Shahmohamadi, Diganta B. Das, Ekanem E. Ekanem, Zhandos Tauanov, Lav Sharma

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Hypothesis: Droplet size in microfluidic devices is affected by wettability of the microfluidic channels. Three-dimensional countercurrent flow focusing using assemblies of chemically inert glass capillaries is expected to minimize wetting of the channel walls by the organic solvent. Experiments: Monodispersed polycaprolactone and poly(lactic acid) particles with a diameter of 18-150. μm were produced by evaporation of solvent (dichloromethane or 1:2 mixture of chloroform and toluene) from oil-in-water or water-in-oil-in-water emulsions produced in three-dimensional flow focusing glass capillary devices. The drop generation behaviour was simulated numerically using the volume of fluid method. Findings: The numerical results showed good agreement with high-speed video recordings. Monodispersed droplets were produced in the dripping regime when the ratio of the continuous phase flow rate to dispersed phase flow rate was 5-20 and the Weber number of the dispersed phase was less than 0.01. The porosity of polycaprolactone particles increased from 8 to 62% when 30. wt% of the water phase was incorporated in the organic phase prior to emulsification. The inner water phase was loaded with 0.156. wt% lidocaine hydrochloride to achieve a sustained drug release. 26% of lidocaine was released after 1. h and more than 93% of the drug was released after 130. h.

    Original languageEnglish
    Pages (from-to)163-170
    Number of pages8
    JournalJournal of Colloid and Interface Science
    Volume418
    DOIs
    Publication statusPublished - Mar 5 2014

    Keywords

    • Computational fluid dynamics
    • Controlled drug release
    • Drop microfluidics
    • Flow focusing
    • Lidocaine hydrochloride
    • Monodispersed microparticle
    • Poly(lactic acid)
    • Polycaprolactone
    • Porous particle
    • Ultrasound contrast agent

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Surfaces, Coatings and Films
    • Colloid and Surface Chemistry

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