Global initiative for interdisciplinary approach to improve innovative clinical research and treatment outcomes in geriatrics: Biological cell-based targeted drug delivery systems for geriatrics

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

At the intersection of the late 20th century and early 21 st century, a worldwide challenge began to emerge-how can the quality of life be improved for a steadily increasing elderly population. It is well known that elderly patients show increased susceptibility to infections and a higher incidence of co-morbidity rates. Older adults frequently demonstrate pharmacokinetic and pharmacodynamic changes promoting adverse drug reactions and complications. Analysis of world literature and practical observations indicate that new approaches are required in gerontology and geriatric medicine due to recent significant advances in biomedical science. Global interdisciplinary approaches to improve medical science and medical care services for growing elderly population are indicated. This global, interdisciplinary initiative should integrate select, tangible clinical results achieved in leading research centers and universities that are applicable in the field of geriatrics and helpful to geriatricians. Among past scientific and clinically significant study results in the field of biomedicine, one must consider targeted drug delivery systems (DDS), which are designed to minimize drug side effects, increase the efficacy of drugs, and prolong and target drug interactions with particular pathological foci in sick patients. Many review articles focus on various methods of drug encapsulation and pharmacokinetics, but not on developing clinical modalities. This article attempts to further the discussion with researchers and clinicians from various fields, as well as to encourage comprehensive and elderly patient-oriented research focused on clinical implementation of DDS, especially erythrocyte-based DDS.

Original languageEnglish
Pages (from-to)212-223
Number of pages12
JournalRejuvenation Research
Volume16
Issue number3
DOIs
Publication statusPublished - Jun 1 2013

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Drug Delivery Systems
Geriatrics
Drug-Related Side Effects and Adverse Reactions
Research
Pharmacokinetics
Drug Interactions
Pharmaceutical Preparations
Population
Erythrocytes
Quality of Life
Research Personnel
Medicine
Morbidity
Incidence
Infection

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

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abstract = "At the intersection of the late 20th century and early 21 st century, a worldwide challenge began to emerge-how can the quality of life be improved for a steadily increasing elderly population. It is well known that elderly patients show increased susceptibility to infections and a higher incidence of co-morbidity rates. Older adults frequently demonstrate pharmacokinetic and pharmacodynamic changes promoting adverse drug reactions and complications. Analysis of world literature and practical observations indicate that new approaches are required in gerontology and geriatric medicine due to recent significant advances in biomedical science. Global interdisciplinary approaches to improve medical science and medical care services for growing elderly population are indicated. This global, interdisciplinary initiative should integrate select, tangible clinical results achieved in leading research centers and universities that are applicable in the field of geriatrics and helpful to geriatricians. Among past scientific and clinically significant study results in the field of biomedicine, one must consider targeted drug delivery systems (DDS), which are designed to minimize drug side effects, increase the efficacy of drugs, and prolong and target drug interactions with particular pathological foci in sick patients. Many review articles focus on various methods of drug encapsulation and pharmacokinetics, but not on developing clinical modalities. This article attempts to further the discussion with researchers and clinicians from various fields, as well as to encourage comprehensive and elderly patient-oriented research focused on clinical implementation of DDS, especially erythrocyte-based DDS.",
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