Glomerulonephritis associated with tuberculosis: A case report and literature review

Yalcin Solak, Abduzhappar Gaipov, Melih Anil, Huseyin Atalay, Orhan Ozbek, Kultigin Turkmen, Ilker Polat, Suleyman Turk

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Rapidly progressive glomerulonephritis caused mycobacterium tuberculosis is rare; however, three case have been reported to date. Crescentic glomerulonephritis is a life-threatening disease and together with the presence of tuberculous infection is associated with a poor outcome if treatment is inadequate and delayed. We describe the case of a 31-year-old female patient with nephrotic syndrome and progressive renal failure secondary to pulmonary tuberculosis. Renal biopsy showed crescent formation in 14 out of 27 glomeruli, and there was diffuse linear staining of immunoglobulin G deposits. Treatment included corticosteroids in combination with antituberculosis drugs for 2 months, and resulted in a significant improvement in renal function, the disappearance of proteinuria and pulmonary symptoms. We also present a review of the pertinent literature and discuss the pathophysiology of tuberculosis-related acute postinfectious glomerulonephritis.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalKaohsiung Journal of Medical Sciences
Volume29
Issue number6
DOIs
Publication statusPublished - Jun 1 2013
Externally publishedYes

Keywords

  • Anti-tuberculosis treatment
  • Crescentic glomerulonephritis
  • Pulmonary tuberculosis
  • Renal failure

ASJC Scopus subject areas

  • Medicine(all)

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